Seroatlas · Human Serome Atlas

LIMD2

LIM domain-containing protein 2

Also known as: LIMD2_HUMAN, MGC10986

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BT23
Gene: LIMD2
Ensembl: ENSG00000136490
Chromosome: 17
Canonical length: 127 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

127 residues, UniProt reviewed canonical sequence.

>Q9BT23|LIMD2
     1  MFQAAGAAQA TPSHDAKGGG SSTVQRSKSF SLRAQVKETC AACQKTVYPM ERLVADKLIF
    61  HNSCFCCKHC HTKLSLGSYA ALHGEFYCKP HFQQLFKSKG NYDEGFGRKQ HKELWAHKEV
   121  DPGTKTA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LIMD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 208 nTPM

Expression across tissuesHPA

Tissue

lymph node: 208 nTPM
spleen: 164 nTPM
tonsil: 140 nTPM
bone marrow: 106 nTPM
thymus: 104 nTPM
appendix: 101 nTPM

Single-cell type

neutrophils: 6.3 nCPM
kupffer cells: 5.1 nCPM
monocytes: 4.3 nCPM
b-cells: 4.2 nCPM
cdc: 4.1 nCPM
nk-cells: 3.4 nCPM

Immune cell

basophil: 2,157 nTPM
eosinophil: 1,439 nTPM
neutrophil: 1,255 nTPM
total PBMC: 992 nTPM
naive B-cell: 858 nTPM
non-classical monocyte: 788 nTPM

Brain region

basal ganglia: 34 nTPM
hippocampal formation: 32 nTPM
cerebral cortex: 30 nTPM
amygdala: 23 nTPM
white matter: 19 nTPM
medulla oblongata: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.01
gnomAD pLI: 0.16
gnomAD missense Z: 0.62
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

actin filament bundle assembly

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LIMD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LIMD2 as an antibody target. Whether an autoantibody or antibody against LIMD2 could matter depends on whether native LIMD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LIMD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LIMD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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