Seroatlas · Human Serome Atlas

CCDC25

Coiled-coil domain-containing protein 25

Also known as: CCD25_HUMAN, FLJ10853

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86WR0
Gene: CCDC25
Ensembl: ENSG00000147419
Chromosome: 8
Canonical length: 208 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

Enables DNA binding activity. Involved in positive regulation of cell motility. Located in endomembrane system and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

208 residues, UniProt reviewed canonical sequence.

>Q86WR0|CCDC25
     1  MVFYFTSSSV NSSAYTIYMG KDKYENEDLI KHGWPEDIWF HVDKLSSAHV YLRLHKGENI
    61  EDIPKEVLMD CAHLVKANSI QGCKMNNVNV VYTPWSNLKK TADMDVGQIG FHRQKDVKIV
   121  TVEKKVNEIL NRLEKTKVER FPDLAAEKEC RDREERNEKK AQIQEMKKRE KEEMKKKREM
   181  DELRSYSSLM KVENMSSNQD GNDSDEFM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

duodenum: 37 nTPM
liver: 31 nTPM
small intestine: 29 nTPM
skeletal muscle: 27 nTPM
kidney: 22 nTPM
stomach: 20 nTPM

Single-cell type

late spermatids: 234 nCPM
late primary spermatocytes: 180 nCPM
gastric progenitor cells: 176 nCPM
early spermatids: 175 nCPM
enterocytes: 174 nCPM
hepatocytes: 172 nCPM

Immune cell

T-reg: 32 nTPM
plasmacytoid DC: 31 nTPM
memory B-cell: 30 nTPM
memory CD4 T-cell: 28 nTPM
basophil: 28 nTPM
naive CD8 T-cell: 28 nTPM

Brain region

white matter: 22 nTPM
cerebral cortex: 22 nTPM
thalamus: 20 nTPM
spinal cord: 20 nTPM
hypothalamus: 20 nTPM
medulla oblongata: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.76
gnomAD pLI: 0.01
gnomAD missense Z: 1.55
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of cell motility

Molecular functions

DNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC25 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC25 as an antibody target. Whether an autoantibody or antibody against CCDC25 could matter depends on whether native CCDC25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC25 is annotated at the cell surface, where native CCDC25 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CCDC25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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