Seroatlas · Human Serome Atlas

SPATA1

Spermatogenesis-associated protein 1

Also known as: SPAT1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VX52
Gene: SPATA1
Canonical length: 459 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for SPATA1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

459 residues, UniProt reviewed canonical sequence.

>Q5VX52|SPATA1
     1  MKKDKKRNKI PIDNYPIQTL VNMSLNPSRP SSSELVELHV FYVPEGSWNY KLNTISTEVV
    61  NKFISAGFLR VSPQLTLRAL RERLGEFLGE DAIAEKFLFL KCIGNNLAVV KEKQESELKL
   121  KSFAPPYALQ PELYLLPVMD HLGNVYSPST VILDERQTNN GVNEADGTIH RPISVTLFKE
   181  ELGRDPSLLE NTLKELPNKN QEEAGGKATA EKSQIAKNQI GNSELPGSLE DSNNDCFGTK
   241  KSQCLWENED DTAISRRQDN QTAEKEYITL PDHPSLPCQP VLSSGITDIS LLQTEREKII
   301  KQMKQVKEER RYLERNREEL VKTVEKLFEQ SKLKRYHAYN GWKKKYLETK KVTASMEEVL
   361  TKLREDLELY YKKLLMQLEA REIKMRPKNL ANITDSKNYL IIQITEVQHA IDQLKRKLDT
   421  DKMKLIVEVK MRKQAVSDLR TLKTELAQKK KIIHLYNLN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 1 nTPM

Expression across tissuesHPA

Tissue

testis: 1 nTPM
bone marrow: 0.3 nTPM
appendix: 0.2 nTPM
liver: 0.2 nTPM
adrenal gland: 0.1 nTPM
gallbladder: 0.1 nTPM

Single-cell type

cardiomyocytes: 251 nCPM
adipocytes: 118 nCPM
pituicytes/fscs: 94 nCPM
early spermatids: 91 nCPM
epicardial cells: 82 nCPM
neutrophils: 75 nCPM

Immune cell

neutrophil: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

medulla oblongata: 0.9 nTPM
cerebellum: 0.8 nTPM
choroid plexus: 0.8 nTPM
hypothalamus: 0.7 nTPM
pons: 0.7 nTPM
white matter: 0.7 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

acrosomal vesicle

Protein domainsUniProt · Pfam · InterPro

Spermatogenesis-associated protein 1, C-terminal domain
Spermatogenesis-associated protein 1
Spermatogenesis-associated C-terminus

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SPATA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

IFT20

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATA1 as an antibody target. Whether an autoantibody or antibody against SPATA1 could matter depends on whether native SPATA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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