Seroatlas · Human Serome Atlas

IFT46

Intraflagellar transport protein 46 homolog

Also known as: C11orf2, C11orf60, CFAP32, FLJ21827, IFT46_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NQC8
Gene
IFT46
Ensembl
ENSG00000118096
Chromosome
11
Canonical length
304 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Actin filaments,Primary cilium,Principal piece

OverviewNCBI Gene

Predicted to be involved in cilium assembly; intraciliary transport; and protein stabilization. Predicted to act upstream of or within smoothened signaling pathway. Located in cytoplasm. Part of intraciliary transport particle B. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

304 residues, UniProt reviewed canonical sequence.

>Q9NQC8|IFT46
     1  MADNSSDECE EENNKEKKKT SQLTPQRGFS ENEDDDDDDD DSSETDSDSD DDDEEHGAPL
    61  EGAYDPADYE HLPVSAEIKE LFQYISRYTP QLIDLDHKLK PFIPDFIPAV GDIDAFLKVP
   121  RPDGKPDNLG LLVLDEPSTK QSDPTVLSLW LTENSKQHNI TQHMKVKSLE DAEKNPKAID
   181  TWIESISELH RSKPPATVHY TRPMPDIDTL MQEWSPEFEE LLGKVSLPTA EIDCSLAEYI
   241  DMICAILDIP VYKSRIQSLH LLFSLYSEFK NSQHFKALAE GKKAFTPSSN STSQAGDMET
   301  LTFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFT46 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
67 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 67 nTPM
  • fallopian tube: 63 nTPM
  • cerebellum: 34 nTPM
  • retina: 33 nTPM
  • pituitary gland: 31 nTPM
  • hypothalamus: 31 nTPM

Single-cell type

  • fallopian tube ciliated cells: 171 nCPM
  • epididymal efferent duct ciliated cells: 123 nCPM
  • respiratory ciliated cells: 116 nCPM
  • ependymal cells: 93 nCPM
  • endometrial ciliated cells: 88 nCPM
  • cardiomyocytes: 81 nCPM

Immune cell

  • memory B-cell: 11 nTPM
  • NK-cell: 11 nTPM
  • MAIT T-cell: 9.9 nTPM
  • T-reg: 9.9 nTPM
  • naive CD4 T-cell: 9.3 nTPM
  • gdT-cell: 8.6 nTPM

Brain region

  • midbrain: 47 nTPM
  • choroid plexus: 46 nTPM
  • cerebellum: 38 nTPM
  • medulla oblongata: 36 nTPM
  • hypothalamus: 36 nTPM
  • cerebral cortex: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.54
gnomAD pLI
0.17
gnomAD missense Z
0.67
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Intraflagellar transport complex B protein 46
  • Intraflagellar transport complex B protein 46 C terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IFT46 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFT46 as an antibody target. Whether an autoantibody or antibody against IFT46 could matter depends on whether native IFT46 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFT46 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IFT46 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IFT46. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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