Seroatlas · Human Serome Atlas

KXD1

KxDL motif-containing protein 1

Also known as: BORCS4, C19orf50, FLJ25480, KXDL, KXDL1_HUMAN, MGC2749

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BQD3
Gene: KXD1
Ensembl: ENSG00000105700
Chromosome: 19
Canonical length: 176 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli fibrillar center,Centrosome,Cytosol

OverviewNCBI Gene

Involved in lysosome localization. Part of BORC complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

176 residues, UniProt reviewed canonical sequence.

>Q9BQD3|KXD1
     1  MDLPDSASRV FCGRILSMVN TDDVNAIILA QKNMLDRFEK TNEMLLNFNN LSSARLQQMS
    61  ERFLHHTRTL VEMKRDLDSI FRRIRTLKGK LARQHPEAFS HIPEASFLEE EDEDPIPPST
   121  TTTIATSEQS TGSCDTSPDT VSPSLSPGFE DLSHVQPGSP AINGRSQTDD EEMTGE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KXD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 110 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 110 nTPM
spinal cord: 108 nTPM
liver: 100 nTPM
skeletal muscle: 95 nTPM
pancreas: 91 nTPM
spleen: 89 nTPM

Single-cell type

early spermatids: 236 nCPM
hofbauer cells: 146 nCPM
extravillous trophoblasts: 144 nCPM
esophageal suprabasal cells: 135 nCPM
esophageal basal cells: 129 nCPM
syncytiotrophoblasts: 127 nCPM

Immune cell

non-classical monocyte: 126 nTPM
intermediate monocyte: 125 nTPM
classical monocyte: 110 nTPM
neutrophil: 108 nTPM
T-reg: 104 nTPM
myeloid DC: 100 nTPM

Brain region

white matter: 110 nTPM
medulla oblongata: 110 nTPM
cerebral cortex: 106 nTPM
midbrain: 98 nTPM
pons: 95 nTPM
thalamus: 95 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0.03
gnomAD missense Z: 0.9
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KxDL domain
KxDL motif-containing protein 1-like
Uncharacterized conserved protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KXD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KXD1 as an antibody target. Whether an autoantibody or antibody against KXD1 could matter depends on whether native KXD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KXD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KXD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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