Seroatlas · Human Serome Atlas

CCDC146

Coiled-coil domain-containing protein 146

Also known as: CC146_HUMAN, KIAA1505, MBO2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IYE0
Gene: CCDC146
Ensembl: ENSG00000135205
Chromosome: 7
Canonical length: 955 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Involved in spermatid development. Located in several cellular components, including microtubule organizing center; midbody; and sperm flagellum. Implicated in spermatogenic failure 94. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

955 residues, UniProt reviewed canonical sequence.

>Q8IYE0|CCDC146
     1  MEDSSTDTEK EEEEEKDEKD QEPIYAIVPT INIQDERFVD LSETPAFIFL HELHAMGKLP
    61  GTRMAALKAK YTLLHDAVMS TQESEVQLLQ NAKRFTEQIQ QQQFHLQQAD NFPEAFSTEV
   121  SKMREQLLKY QNEYNAVKER EFHNQYRLNS LKEEKIIIVK EFEKITKPGE MEKKMKILRE
   181  STEELRKEIM QKKLEIKNLR EDLASKQKQL LKEQKELEEL LGHQVVLKDE VAHHQTIPVQ
   241  IGKEIEKITR KKVEMEKKKI VLEQEVKTLN DSLKKVENKV SAIVDEKENV IKEVEGKRAL
   301  LEIKEREHNQ LVKLLELARE NEATSLTERG ILDLNLRNSL IDKQNYHDEL SRKQREKERD
   361  FRNLRKMELL LKVSWDALRQ TQALHQRLLL EMEAIPKDDS TLSERRRELH KEVEVAKRNL
   421  AQQKIISEME SKLVEQQLAE ENKLLKEQEN MKELVVNLLR MTQIKIDEKE QKSKDFLKAQ
   481  QKYTNIVKEM KAKDLEIRIH KKKKCEIYRR LREFAKLYDT IRNERNKFVN LLHKAHQKVN
   541  EIKERHKMSL NELEILRNSA VSQERKLQNS MLKHANNVTI RESMQNDVRK IVSKLQEMKE
   601  KKEAQLNNID RLANTITMIE EEMVQLRKRY EKAVQHRNES GVQLIEREEE ICIFYEKINI
   661  QEKMKLNGEI EIHLLEEKIQ FLKMKIAEKQ RQICVTQKLL PAKRSLDADL AVLQIQFSQC
   721  TDRIKDLEKQ FVKPDGENRA RFLPGKDLTE KEMIQKLDKL ELQLAKKEEK LLEKDFIYEQ
   781  VSRLTDRLCS KTQGCKQDTL LLAKKMNGYQ RRIKNATEKM MALVAELSMK QALTIELQKE
   841  VREKEDFIFT CNSRIEKGLP LNKEIEKEWL KVLRDEEMHA LAIAEKSQEF LEADNRQLPN
   901  GVYTTAEQRP NAYIPEADAT LPLPKPYGAL APFKPSEPGA NMRHIRKPVI KPVEI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC146 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 32 nTPM
testis: 20 nTPM
choroid plexus: 16 nTPM
retina: 13 nTPM
skin: 8.9 nTPM
thyroid gland: 7.2 nTPM

Single-cell type

respiratory ciliated cells: 1,055 nCPM
epididymal efferent duct ciliated cells: 953 nCPM
fallopian tube ciliated cells: 806 nCPM
ependymal cells: 731 nCPM
endometrial ciliated cells: 702 nCPM
epididymal efferent duct absorptive cells: 595 nCPM

Immune cell

neutrophil: 16 nTPM
eosinophil: 14 nTPM
NK-cell: 5.4 nTPM
gdT-cell: 4.4 nTPM
memory CD8 T-cell: 3.1 nTPM
MAIT T-cell: 3 nTPM

Brain region

choroid plexus: 45 nTPM
medulla oblongata: 32 nTPM
midbrain: 31 nTPM
spinal cord: 23 nTPM
white matter: 19 nTPM
pons: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCDC146.

Disease | AllUniProt

Conditions CCDC146 is implicated in, by any mechanism.

Spermatogenic failure 94 (SPGF94) MIM:620850

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 155 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Spermatogenic failure 94
Male infertility with spermatogenesis disorder due to single gene mutation
Male infertility due to sperm motility disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
gnomAD missense Z: 0.88
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein-containing complex binding

Cellular components

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC146 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC146 as an antibody target. Whether an autoantibody or antibody against CCDC146 could matter depends on whether native CCDC146 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC146 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC146 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...