Seroatlas · Human Serome Atlas

IFT88

Intraflagellar transport protein 88 homolog

Also known as: D13S1056E, hTg737, IFT88_HUMAN, MGC26259, Tg737, TTC10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13099
Gene: IFT88
Ensembl: ENSG00000032742
Chromosome: 13
Canonical length: 824 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Microtubules,Cytokinetic bridge,Mitotic spindle,Primary cilium,Centriolar satellite,Basal body,Cytosol,Connecting piece,Mid piece,Principal piece,End piece

OverviewNCBI Gene

This gene encodes a member of the tetratrico peptide repeat (TPR) family. The encoded protein is involved in cilium biogenesis. Mutations of a similar gene in mouse can cause polycystic kidney disease. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2017]

Canonical amino-acid sequenceUniProt

824 residues, UniProt reviewed canonical sequence.

>Q13099|IFT88
     1  MMQNVHLAPE TDEDDLYSGY NDYNPIYDIE ELENDAAFQQ AVRTSHGRRP PITAKISSTA
    61  VTRPIATGYG SKTSLASSIG RPMTGAIQDG VTRPMTAVRA AGFTKAALRG SAFDPLSQSR
   121  GPASPLEAKK KDSPEEKIKQ LEKEVNELVE ESCIANSCGD LKLALEKAKD AGRKERVLVR
   181  QREQVTTPEN INLDLTYSVL FNLASQYSVN EMYAEALNTY QVIVKNKMFS NAGILKMNMG
   241  NIYLKQRNYS KAIKFYRMAL DQVPSVNKQM RIKIMQNIGV TFIQAGQYSD AINSYEHIMS
   301  MAPNLKAGYN LTICYFAIGD REKMKKAFQK LITVPLEIDE DKYISPSDDP HTNLVTEAIK
   361  NDHLRQMERE RKAMAEKYIM TSAKLIAPVI ETSFAAGYDW CVEVVKASQY VELANDLEIN
   421  KAVTYLRQKD YNQAVEILKV LEKKDSRVKS AAATNLSALY YMGKDFAQAS SYADIAVNSD
   481  RYNPAALTNK GNTVFANGDY EKAAEFYKEA LRNDSSCTEA LYNIGLTYEK LNRLDEALDC
   541  FLKLHAILRN SAEVLYQIAN IYELMENPSQ AIEWLMQVVS VIPTDPQVLS KLGELYDREG
   601  DKSQAFQYYY ESYRYFPCNI EVIEWLGAYY IDTQFWEKAI QYFERASLIQ PTQVKWQLMV
   661  ASCFRRSGNY QKALDTYKDT HRKFPENVEC LRFLVRLCTD LGLKDAQEYA RKLKRLEKMK
   721  EIREQRIKSG RDGSGGSRGK REGSASGDSG QNYSASSKGE RLSARLRALP GTNEPYESSS
   781  NKEIDASYVD PLGPQIERPK TAAKKRIDED DFADEELGDD LLPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFT88 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 66 nTPM

Expression across tissuesHPA

Tissue

testis: 66 nTPM
retina: 30 nTPM
kidney: 21 nTPM
fallopian tube: 18 nTPM
thyroid gland: 18 nTPM
liver: 15 nTPM

Single-cell type

ependymal cells: 505 nCPM
respiratory ciliated cells: 454 nCPM
rod photoreceptor cells: 390 nCPM
early primary spermatocytes: 375 nCPM
late primary spermatocytes: 333 nCPM
fallopian tube ciliated cells: 308 nCPM

Immune cell

neutrophil: 7.4 nTPM
NK-cell: 6.3 nTPM
naive B-cell: 6 nTPM
naive CD8 T-cell: 5.8 nTPM
memory B-cell: 5.5 nTPM
non-classical monocyte: 4.5 nTPM

Brain region

white matter: 38 nTPM
choroid plexus: 37 nTPM
midbrain: 34 nTPM
medulla oblongata: 32 nTPM
spinal cord: 32 nTPM
basal ganglia: 32 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IFT88.

Disease | ImmuneIEDB

Conditions an epitope on IFT88 was assayed in.

narcolepsy B cell
multiple sclerosis B cell
peripheral nervous system disease B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0
gnomAD missense Z: 0.34
DepMap mean gene effect: -0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

kinesin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IFT88 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFT88 as an antibody target. Whether an autoantibody or antibody against IFT88 could matter depends on whether native IFT88 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFT88 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IFT88 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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