Seroatlas · Human Serome Atlas

DEUP1

Deuterosome assembly protein 1

Also known as: CCDC67, DEUP1_HUMAN, FLJ25393

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q05D60
Gene
DEUP1
Ensembl
ENSG00000165325
Chromosome
11
Canonical length
604 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in centriole replication and de novo centriole assembly involved in multi-ciliated epithelial cell differentiation. Predicted to be located in cytoplasm and membrane. Predicted to be active in centriole and deuterosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

604 residues, UniProt reviewed canonical sequence.

>Q05D60|DEUP1
     1  MENQAHNTMG TSPCEAELQE LMEQIDIMVS NKKMDWERKM RALETRLDLR DQELANAQTC
    61  LDQKGQEVGL LRQKLDSLEK CNLAMTQNYE GQLQSLKAQF SKLTNNFEKL RLHQMKQNKV
   121  PRKELPHLKE EIPFELSNLN QKLEEFRAKS REWDKQEILY QTHLISLDAQ QKLLSEKCNQ
   181  FQKQAQSYQT QLNGKKQCLE DSSSEIPRLI CDPDPNCEIN ERDEFIIEKL KSAVNEIALS
   241  RNKLQDENQK LLQELKMYQR QCQAMEAGLS EVKSELQSRD DLLRIIEMER LQLHRELLKI
   301  GECQNAQGNK TRLESSYLPS IKEPERKIKE LFSVMQDQPN HEKELNKIRS QLQQVEEYHN
   361  SEQERMRNEI SDLTEELHQK EITIATVTKK AALLEKQLKM ELEIKEKMLA KQKVSDMKYK
   421  AVRTENTHLK GMMGDLDPGE YMSMDFTNRE QSRHTSINKL QYENERLRND LAKLHVNGKS
   481  TWTNQNTYEE TGRYAYQSQI KVEQNEERLS HDCEPNRSTM PPLPPSTFQA KEMTSPLVSD
   541  DDVFPLSPPD MSFPASLAAQ HFLLEEEKRA KELEKLLNTH IDELQRHTEF TLNKYSKLKQ
   601  NRHI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DEUP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • testis: 15 nTPM
  • fallopian tube: 4.5 nTPM
  • pituitary gland: 1.4 nTPM
  • choroid plexus: 1.2 nTPM
  • epididymis: 1.1 nTPM
  • thyroid gland: 0.9 nTPM

Single-cell type

  • late primary spermatocytes: 338 nCPM
  • late spermatids: 244 nCPM
  • early spermatids: 235 nCPM
  • respiratory deuterosomal cells: 115 nCPM
  • cardiomyocytes: 80 nCPM
  • fallopian tube ciliated cells: 64 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 8.4 nTPM
  • choroid plexus: 4.8 nTPM
  • midbrain: 3.2 nTPM
  • medulla oblongata: 2.5 nTPM
  • white matter: 2.5 nTPM
  • pons: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.99
gnomAD pLI
0
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DEUP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DEUP1 as an antibody target. Whether an autoantibody or antibody against DEUP1 could matter depends on whether native DEUP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DEUP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DEUP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DEUP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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