Seroatlas · Human Serome Atlas

IFT70B

Intraflagellar transport protein 70B

Also known as: fleer, FLJ30990, IT70B_HUMAN, TTC30B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N4P2
Gene
IFT70B
Ensembl
ENSG00000196659
Chromosome
2
Canonical length
665 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Primary cilium,Primary cilium tip,Centrosome,Basal body

OverviewNCBI Gene

Predicted to enable intraciliary transport particle B binding activity. Predicted to be involved in intraciliary transport. Part of intraciliary transport particle B. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

665 residues, UniProt reviewed canonical sequence.

>Q8N4P2|IFT70B
     1  MAGLSGAQIP DGEFTAVVYR LIRNARYAEA VQLLGGELQR SPRSRAGLSL LGYCYYRLQE
    61  FALAAECYEQ LGQLHPELEQ YRLYQAQALY KACLYAEATR VAFLLLDNPA YHSRVLRLQA
   121  AIKYSEGDLP GSRSLVEQLP SREGGEESGG ENETDGQINL GCLLYKEGQY EAACSKFFAA
   181  LQASGYQPDL SYNLALAYYS SRQYASALKH IAEIIERGIR QHPELGVGMT TEGIDVRSVG
   241  NTLVLHQTAL VEAFNLKAAI EYQLRNYEAA QEALTDMPPR AEEELDPVTL HNQALMNMDA
   301  RPTEGFEKLQ FLLQQNPFPP ETFGNLLLLY CKYEYFDLAA DVLAENAHLI YKFLTPYLYD
   361  FLDAVITCQT APEEAFIKLD GLAGMLTEVL RKLTIQVQEA RHNRDDEAIK KAVNEYDETM
   421  EKYIPVLMAQ AKIYWNLENY PMVEKIFRKS VEFCNDHDVW KLNVAHVLFM QENKYKEAIG
   481  FYEPIVKKHY DNILNVSAIV LANLCVSYIM TSQNEEAEEL MRKIEKEEEQ LSYDDPDKKM
   541  YHLCIVNLVI GTLYCAKGNY DFGISRVIKS LEPYNKKLGT DTWYYAKRCF LSLLENMSKH
   601  TIMLRDSVIQ ECVQFLEHCE LHGRNIPAVI EQPLEEERMH VGKNTVTYES RQLKALIYEI
   661  IGWNI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFT70B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
9.7 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 9.7 nTPM
  • thyroid gland: 7.6 nTPM
  • testis: 6.5 nTPM
  • epididymis: 6.4 nTPM
  • breast: 5 nTPM
  • parathyroid gland: 4.8 nTPM

Single-cell type

  • respiratory ciliated cells: 54 nCPM
  • fallopian tube ciliated cells: 34 nCPM
  • late primary spermatocytes: 30 nCPM
  • ependymal cells: 18 nCPM
  • cardiomyocytes: 17 nCPM
  • endometrial ciliated cells: 17 nCPM

Immune cell

  • basophil: 2.7 nTPM
  • myeloid DC: 1.6 nTPM
  • classical monocyte: 1.4 nTPM
  • naive B-cell: 1.4 nTPM
  • intermediate monocyte: 1.3 nTPM
  • eosinophil: 1.2 nTPM

Brain region

  • choroid plexus: 7 nTPM
  • midbrain: 5.4 nTPM
  • spinal cord: 5.4 nTPM
  • white matter: 5.2 nTPM
  • medulla oblongata: 4.9 nTPM
  • hypothalamus: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.13
gnomAD pLI
0
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IFT70B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFT70B as an antibody target. Whether an autoantibody or antibody against IFT70B could matter depends on whether native IFT70B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFT70B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IFT70B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IFT70B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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