Seroatlas · Human Serome Atlas

IFT70A

Intraflagellar transport protein 70A

Also known as: FAP259, FLJ13946, IT70A_HUMAN, TTC30A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86WT1
Gene: IFT70A
Ensembl: ENSG00000197557
Chromosome: 2
Canonical length: 665 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Primary cilium,Primary cilium tip,Centrosome,Basal body

OverviewNCBI Gene

Predicted to enable intraciliary transport particle B binding activity. Predicted to be involved in intraciliary transport. Predicted to be located in centrosome. Predicted to be part of intraciliary transport particle B. Predicted to be active in axonemal microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

665 residues, UniProt reviewed canonical sequence.

>Q86WT1|IFT70A
     1  MAGLSGAQIP DGEFTALVYR LIRDARYAEA VQLLGRELQR SPRSRAGLSL LGYCYYRLQE
    61  FALAAECYEQ LGQLHPELEQ YRLYQAQALY KACLYPEATR VAFLLLDNPA YHSRVLRLQA
   121  AIKYSEGDLP GSRSLVEQLL SGEGGEESGG DNETDGQVNL GCLLYKEGQY EAACSKFSAT
   181  LQASGYQPDL SYNLALAYYS SRQYASALKH IAEIIERGIR QHPELGVGMT TEGFDVRSVG
   241  NTLVLHQTAL VEAFNLKAAI EYQLRNYEVA QETLTDMPPR AEEELDPVTL HNQALMNMDA
   301  RPTEGFEKLQ FLLQQNPFPP ETFGNLLLLY CKYEYFDLAA DVLAENAHLT YKFLTPYLYD
   361  FLDALITCQT APEEAFIKLD GLAGMLTEQL RRLTKQVQEA RHNRDDEAIK KAVNEYDETM
   421  EKYIPVLMAQ AKIYWNLENY PMVEKVFRKS VEFCNDHDVW KLNVAHVLFM QENKYKEAIG
   481  FYEPIVKKHY DNILNVSAIV LANLCVSYIM TSQNEEAEEL MRKIEKEEEQ LSYDDPNRKM
   541  YHLCIVNLVI GTLYCAKGNY EFGISRVIKS LEPYNKKLGT DTWYYAKRCF LSLLENMSKH
   601  MIVIHDSVIQ ECVQFLGHCE LYGTNIPAVI EQPLEEERMH VGKNTVTDES RQLKALIYEI
   661  IGWNK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFT70A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 9.2 nTPM

Expression across tissuesHPA

Tissue

testis: 9.2 nTPM
retina: 7.6 nTPM
epididymis: 7.4 nTPM
thyroid gland: 6.7 nTPM
fallopian tube: 5.9 nTPM
parathyroid gland: 5.3 nTPM

Single-cell type

late primary spermatocytes: 123 nCPM
early spermatids: 35 nCPM
respiratory ciliated cells: 32 nCPM
fallopian tube ciliated cells: 21 nCPM
early primary spermatocytes: 15 nCPM
endometrial ciliated cells: 13 nCPM

Immune cell

naive CD4 T-cell: 0.5 nTPM
eosinophil: 0.4 nTPM
intermediate monocyte: 0.4 nTPM
classical monocyte: 0.3 nTPM
myeloid DC: 0.3 nTPM
non-classical monocyte: 0.3 nTPM

Brain region

choroid plexus: 8.8 nTPM
medulla oblongata: 5.8 nTPM
spinal cord: 5.8 nTPM
midbrain: 5.7 nTPM
white matter: 5.7 nTPM
hypothalamus: 4.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

intraciliary transport

Molecular functions

intraciliary transport particle B binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IFT70A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFT70A as an antibody target. Whether an autoantibody or antibody against IFT70A could matter depends on whether native IFT70A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFT70A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IFT70A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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