LCMT1

Protein identityUniProt · HPA

UniProt accession

Q9UIC8

Gene

LCMT1

Ensembl

ENSG00000205629

Chromosome

16

Canonical length

334 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA; MIM 176915) (De Baere et al., 1999 [PubMed 10600115]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

334 residues, UniProt reviewed canonical sequence.

>Q9UIC8|LCMT1
     1  MATRQRESSI TSCCSTSSCD ADDEGVRGTC EDASLCKRFA VSIGYWHDPY IQHFVRLSKE
    61  RKAPEINRGY FARVHGVSQL IKAFLRKTEC HCQIVNLGAG MDTTFWRLKD EDLLPSKYFE
   121  VDFPMIVTRK LHSIKCKPPL SSPILELHSE DTLQMDGHIL DSKRYAVIGA DLRDLSELEE
   181  KLKKCNMNTQ LPTLLIAECV LVYMTPEQSA NLLKWAANSF ERAMFINYEQ VNMGDRFGQI
   241  MIENLRRRQC DLAGVETCKS LESQKERLLS NGWETASAVD MMELYNRLPR AEVSRIESLE
   301  FLDEMELLEQ LMRHYCLCWA TKGGNELGLK EITY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LCMT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

51 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.87

gnomAD pLI

0

gnomAD missense Z

0.63

DepMap mean gene effect

-0.34

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• C-terminal protein methylation
• G2/M transition of mitotic cell cycle
• negative regulation of protein-containing complex assembly
• protein methylation
• protein modification process
• regulation of apoptotic process
• regulation of glucose metabolic process
• regulation of mitotic cell cycle spindle assembly checkpoint

Molecular functions

• protein C-terminal carboxyl O-methyltransferase activity
• S-adenosylmethionine-dependent methyltransferase activity
• protein C-terminal leucine carboxyl O-methyltransferase activity

Cellular components

• cytosol
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• Methyltransferase Ppm1/Ppm2/Tcmp
• S-adenosyl-L-methionine-dependent methyltransferase superfamily
• Leucine carboxyl methyltransferase
• Leucine carboxyl methyltransferase 1

KeywordsUniProt

• Methyltransferase
• S-adenosyl-L-methionine
• Transferase

InteractionsUniProt · HPA

Protein binding partners of LCMT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FXR2