Seroatlas · Human Serome Atlas

C10orf62

Uncharacterized protein C10orf62

Also known as: bA548K23.1, CJ062_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T681
Gene: C10orf62
Ensembl: ENSG00000203942
Chromosome: 10
Canonical length: 223 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

No narrative summary is available for C10orf62 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

223 residues, UniProt reviewed canonical sequence.

>Q5T681|C10orf62
     1  MLWVQRKRRR KETSECPSDK DKSPESHKAK NESWIKSHFS RLSEEKLALD NNASASGNAT
    61  QTESGSEEVS STVHIETFTT RHGEVGSALH RESFTSRQKT SGPSVIQEIH QESGKAPSTD
   121  EATWAAVAAC TKEIDTQGRH LAHSMLQRAI AYQHSGHLES KDINQEELRA LEEVEMKLQK
   181  NFLTQRENTI AGANHTHTFY GHSHHSHHGH PSHQSHSLPN RRH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C10orf62 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 263 nTPM

Expression across tissuesHPA

Tissue

testis: 263 nTPM
cerebellum: 0.9 nTPM
heart muscle: 0.8 nTPM
liver: 0.7 nTPM
kidney: 0.6 nTPM
choroid plexus: 0.5 nTPM

Single-cell type

late spermatids: 292 nCPM
early spermatids: 59 nCPM
late primary spermatocytes: 7 nCPM
sertoli cells: 1.1 nCPM
lymphatic endothelial cells: 0.5 nCPM
leydig cells: 0.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 4 nTPM
cerebellum: 3.4 nTPM
white matter: 3.4 nTPM
midbrain: 2.5 nTPM
medulla oblongata: 2.4 nTPM
pons: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0
gnomAD missense Z: 0.14
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Uncharacterized protein C10orf62
Family of unknown function (DUF5569)

KeywordsUniProt

Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of C10orf62 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C10orf62 as an antibody target. Whether an autoantibody or antibody against C10orf62 could matter depends on whether native C10orf62 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C10orf62 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C10orf62 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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