Seroatlas · Human Serome Atlas

RRN3

RNA polymerase I-specific transcription initiation factor RRN3

Also known as: DKFZp566E104, RRN3_HUMAN, TIF-IA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NYV6
Gene
RRN3
Ensembl
ENSG00000085721
Chromosome
16
Canonical length
651 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoli rim

OverviewNCBI Gene

Enables RNA polymerase I core promoter sequence-specific DNA binding activity and RNA polymerase I general transcription initiation factor activity. Involved in transcription initiation at RNA polymerase I promoter. Located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

651 residues, UniProt reviewed canonical sequence.

>Q9NYV6|RRN3
     1  MAAPLLHTRL PGDAAASSSA VKKLGASRTG ISNMRALEND FFNSPPRKTV RFGGTVTEVL
    61  LKYKKGETND FELLKNQLLD PDIKDDQIIN WLLEFRSSIM YLTKDFEQLI SIILRLPWLN
   121  RSQTVVEEYL AFLGNLVSAQ TVFLRPCLSM IASHFVPPRV IIKEGDVDVS DSDDEDDNLP
   181  ANFDTCHRAL QIIARYVPST PWFLMPILVE KFPFVRKSER TLECYVHNLL RISVYFPTLR
   241  HEILELIIEK LLKLDVNASR QGIEDAEETA TQTCGGTDST EGLFNMDEDE ETEHETKAGP
   301  ERLDQMVHPV AERLDILMSL VLSYMKDVCY VDGKVDNGKT KDLYRDLINI FDKLLLPTHA
   361  SCHVQFFMFY LCSFKLGFAE AFLEHLWKKL QDPSNPAIIR QAAGNYIGSF LARAKFIPLI
   421  TVKSCLDLLV NWLHIYLNNQ DSGTKAFCDV ALHGPFYSAC QAVFYTFVFR HKQLLSGNLK
   481  EGLQYLQSLN FERIVMSQLN PLKICLPSVV NFFAAITNKY QLVFCYTIIE RNNRQMLPVI
   541  RSTAGGDSVQ ICTNPLDTFF PFDPCVLKRS KKFIDPIYQV WEDMSAEELQ EFKKPMKKDI
   601  VEDEDDDFLK GEVPQNDTVI GITPSSFDTH FRSPSSSVGS PPVLYMQPSP L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RRN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 40 nTPM
  • tongue: 37 nTPM
  • liver: 29 nTPM
  • bone marrow: 27 nTPM
  • retina: 22 nTPM
  • adipose tissue: 21 nTPM

Single-cell type

  • proximal tubule cells: 30 nCPM
  • renal collecting duct intercalated cells: 29 nCPM
  • distal convoluted tubule cells: 27 nCPM
  • podocytes: 27 nCPM
  • loop of henle epithelial cells: 26 nCPM
  • renal connecting tubule cells: 24 nCPM

Immune cell

  • basophil: 8.2 nTPM
  • NK-cell: 6.9 nTPM
  • MAIT T-cell: 5.3 nTPM
  • memory B-cell: 4.7 nTPM
  • total PBMC: 4.6 nTPM
  • naive CD4 T-cell: 4.2 nTPM

Brain region

  • cerebellum: 14 nTPM
  • midbrain: 12 nTPM
  • white matter: 12 nTPM
  • cerebral cortex: 9.8 nTPM
  • hypothalamus: 9.5 nTPM
  • pons: 9.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.65
gnomAD pLI
0
gnomAD missense Z
-0.77
DepMap mean gene effect
-1.99
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RRN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RRN3 as an antibody target. Whether an autoantibody or antibody against RRN3 could matter depends on whether native RRN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RRN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RRN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RRN3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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