Seroatlas · Human Serome Atlas

FAM53B

Protein FAM53B

Also known as: bA12J10.2, FA53B_HUMAN, KIAA0140, smp

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14153
Gene: FAM53B
Ensembl: ENSG00000189319
Chromosome: 10
Canonical length: 422 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Involved in positive regulation of canonical Wnt signaling pathway. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

422 residues, UniProt reviewed canonical sequence.

>Q14153|FAM53B
     1  MVMVLSESLS TRGADSIACG TFSRELHTPK KMSQGPTLFS CGIMENDRWR DLDRKCPLQI
    61  DQPSTSIWEC LPEKDSSLWH REAVTACAVT SLIKDLSISD HNGNPSAPPS KRQCRSLSFS
   121  DEMSSCRTSW RPLGSKVWTP VEKRRCYSGG SVQRYSNGFS TMQRSSSFSL PSRANVLSSP
   181  CDQAGLHHRF GGQPCQGVPG SAPCGQAGDT WSPDLHPVGG GRLDLQRSLS CSHEQFSFVE
   241  YCPPSANSTP ASTPELARRS SGLSRSRSQP CVLNDKKVGV KRRRPEEVQE QRPSLDLAKM
   301  AQNCQTFSSL SCLSAGTEDC GPQSPFARHV SNTRAWTALL SASGPGGRTP AGTPVPEPLP
   361  PSFDDHLACQ EDLSCEESDS CALDEDCGRR AEPAAAWRDR GAPGNSLCSL DGELDIEQIE
   421  KN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM53B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.72
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 47 nTPM
thymus: 31 nTPM
lymph node: 29 nTPM
bone marrow: 24 nTPM
spinal cord: 24 nTPM
tongue: 21 nTPM

Single-cell type

early spermatids: 15 nCPM
late primary spermatocytes: 11 nCPM
oocytes: 4.6 nCPM
late spermatids: 4 nCPM
epicardial cells: 2.3 nCPM
erythrocyte progenitors: 1.5 nCPM

Immune cell

gdT-cell: 7 nTPM
naive B-cell: 6 nTPM
memory CD8 T-cell: 3.7 nTPM
T-reg: 3.6 nTPM
memory B-cell: 3.5 nTPM
total PBMC: 3.4 nTPM

Brain region

white matter: 110 nTPM
thalamus: 81 nTPM
cerebral cortex: 81 nTPM
basal ganglia: 75 nTPM
medulla oblongata: 71 nTPM
midbrain: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.86
gnomAD missense Z: 1.21
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM53B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM53B as an antibody target. Whether an autoantibody or antibody against FAM53B could matter depends on whether native FAM53B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM53B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM53B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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