PTPRJ

Protein identityUniProt · HPA

UniProt accession

Q12913

Gene

PTPRJ

Ensembl

ENSG00000149177

Chromosome

11

Canonical length

1337 aa

Protein class

CD markers, Enzymes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins

Subcellular location

Nucleoplasm,Nucleoli,Nuclear bodies,Cell Junctions

Secretome location

Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1337 residues, UniProt reviewed canonical sequence.

>Q12913|PTPRJ
     1  MKPAAREARL PPRSPGLRWA LPLLLLLLRL GQILCAGGTP SPIPDPSVAT VATGENGITQ
    61  ISSTAESFHK QNGTGTPQVE TNTSEDGESS GANDSLRTPE QGSNGTDGAS QKTPSSTGPS
   121  PVFDIKAVSI SPTNVILTWK SNDTAASEYK YVVKHKMENE KTITVVHQPW CNITGLRPAT
   181  SYVFSITPGI GNETWGDPRV IKVITEPIPV SDLRVALTGV RKAALSWSNG NGTASCRVLL
   241  ESIGSHEELT QDSRLQVNIS GLKPGVQYNI NPYLLQSNKT KGDPLGTEGG LDASNTERSR
   301  AGSPTAPVHD ESLVGPVDPS SGQQSRDTEV LLVGLEPGTR YNATVYSQAA NGTEGQPQAI
   361  EFRTNAIQVF DVTAVNISAT SLTLIWKVSD NESSSNYTYK IHVAGETDSS NLNVSEPRAV
   421  IPGLRSSTFY NITVCPVLGD IEGTPGFLQV HTPPVPVSDF RVTVVSTTEI GLAWSSHDAE
   481  SFQMHITQEG AGNSRVEITT NQSIIIGGLF PGTKYCFEIV PKGPNGTEGA SRTVCNRTVP
   541  SAVFDIHVVY VTTTEMWLDW KSPDGASEYV YHLVIESKHG SNHTSTYDKA ITLQGLIPGT
   601  LYNITISPEV DHVWGDPNST AQYTRPSNVS NIDVSTNTTA ATLSWQNFDD ASPTYSYCLL
   661  IEKAGNSSNA TQVVTDIGIT DATVTELIPG SSYTVEIFAQ VGDGIKSLEP GRKSFCTDPA
   721  SMASFDCEVV PKEPALVLKW TCPPGANAGF ELEVSSGAWN NATHLESCSS ENGTEYRTEV
   781  TYLNFSTSYN ISITTVSCGK MAAPTRNTCT TGITDPPPPD GSPNITSVSH NSVKVKFSGF
   841  EASHGPIKAY AVILTTGEAG HPSADVLKYT YEDFKKGASD TYVTYLIRTE EKGRSQSLSE
   901  VLKYEIDVGN ESTTLGYYNG KLEPLGSYRA CVAGFTNITF HPQNKGLIDG AESYVSFSRY
   961  SDAVSLPQDP GVICGAVFGC IFGALVIVTV GGFIFWRKKR KDAKNNEVSF SQIKPKKSKL
  1021  IRVENFEAYF KKQQADSNCG FAEEYEDLKL VGISQPKYAA ELAENRGKNR YNNVLPYDIS
  1081  RVKLSVQTHS TDDYINANYM PGYHSKKDFI ATQGPLPNTL KDFWRMVWEK NVYAIIMLTK
  1141  CVEQGRTKCE EYWPSKQAQD YGDITVAMTS EIVLPEWTIR DFTVKNIQTS ESHPLRQFHF
  1201  TSWPDHGVPD TTDLLINFRY LVRDYMKQSP PESPILVHCS AGVGRTGTFI AIDRLIYQIE
  1261  NENTVDVYGI VYDLRMHRPL MVQTEDQYVF LNQCVLDIVR SQKDSKVDLI YQNTTAMTIY
  1321  ENLAPVTTFG KTNGYIA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTPRJ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.35

Highest tissue expression

26 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PTPRJ.

Disease | AllUniProt

Conditions PTPRJ is implicated in, by any mechanism.

• Thrombocytopenia 10 (THC10) MIM:620484

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 262 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Thrombocytopenia 10
• Carcinoma of colon

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.63

gnomAD pLI

0

gnomAD missense Z

0.97

DepMap mean gene effect

-0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• angiogenesis
• axon guidance
• B cell differentiation
• blood coagulation
• contact inhibition
• cytokine-mediated signaling pathway
• glucose homeostasis
• heart development
• negative regulation of cell growth
• negative regulation of cell migration
• negative regulation of cell population proliferation
• negative regulation of epidermal growth factor receptor signaling pathway
• negative regulation of insulin receptor signaling pathway
• negative regulation of MAP kinase activity
• negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
• negative regulation of platelet-derived growth factor receptor signaling pathway
• negative regulation of T cell receptor signaling pathway
• negative regulation of vascular permeability
• oligodendrocyte differentiation
• peptidyl-tyrosine dephosphorylation
• platelet formation
• platelet-derived growth factor receptor signaling pathway
• positive chemotaxis
• positive regulation of calcium-mediated signaling
• positive regulation of cell adhesion
• positive regulation of Fc receptor mediated stimulatory signaling pathway
• positive regulation of focal adhesion assembly
• positive regulation of macrophage chemotaxis
• positive regulation of MAPK cascade
• positive regulation of phagocytosis
• positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
• positive regulation of platelet activation
• positive regulation of tumor necrosis factor production
• regulation of cell adhesion
• signal transduction
• T cell receptor signaling pathway
• vasculogenesis

Molecular functions

• beta-catenin binding
• cadherin binding
• delta-catenin binding
• gamma-catenin binding
• mitogen-activated protein kinase binding
• phosphatase activity
• platelet-derived growth factor receptor binding
• protein kinase binding
• protein tyrosine phosphatase activity

Cellular components

• cell junction
• cell surface
• cell-cell junction
• extracellular exosome
• immunological synapse
• nuclear body
• nucleolus
• nucleoplasm
• plasma membrane
• ruffle membrane
• specific granule membrane

Protein domainsUniProt · Pfam · InterPro

• Tyrosine-specific protein phosphatase, PTPase domain
• Tyrosine-specific protein phosphatases domain
• Protein-tyrosine phosphatase, catalytic
• Fibronectin type III
• Immunoglobulin-like fold
• Protein-tyrosine phosphatase, active site
• Protein-tyrosine phosphatase-like
• Fibronectin type III superfamily
• PTPRJ, transmembrane domain
• Receptor-type Tyrosine-protein Phosphatases/Ushers
• Fibronectin type III domain
• Protein-tyrosine phosphatase
• TM proximal of protein tyrosine phosphatase, receptor type J

KeywordsUniProt

• Alternative initiation
• Angiogenesis
• Cell junction
• Cell membrane
• Cell projection
• Glycoprotein
• Hydrolase
• Membrane
• Phosphoprotein
• Protein phosphatase
• Repeat
• Secreted
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of PTPRJ in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CTNNB1
• FLT3
• GAB1
• GRB2
• JUP
• SDCBP
• CTNND1