Seroatlas · Human Serome Atlas

NDRG2

Protein NDRG2

Also known as: KIAA1248, NDRG2_HUMAN, SYLD

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UN36
Gene
NDRG2
Ensembl
ENSG00000165795
Chromosome
14
Canonical length
371 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Centriolar satellite,Cytosol

OverviewNCBI Gene

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

371 residues, UniProt reviewed canonical sequence.

>Q9UN36|NDRG2
     1  MAELQEVQIT EEKPLLPGQT PEAAKEAELA ARILLDQGQT HSVETPYGSV TFTVYGTPKP
    61  KRPAILTYHD VGLNYKSCFQ PLFQFEDMQE IIQNFVRVHV DAPGMEEGAP VFPLGYQYPS
   121  LDQLADMIPC VLQYLNFSTI IGVGVGAGAY ILARYALNHP DTVEGLVLIN IDPNAKGWMD
   181  WAAHKLTGLT SSIPEMILGH LFSQEELSGN SELIQKYRNI ITHAPNLDNI ELYWNSYNNR
   241  RDLNFERGGD ITLRCPVMLV VGDQAPHEDA VVECNSKLDP TQTSFLKMAD SGGQPQLTQP
   301  GKLTEAFKYF LQGMGYMASS CMTRLSRSRT ASLTSAASVD GNRSRSRTLS QSSESGTLSS
   361  GPPGHTMEVS C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NDRG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
2,060 nTPM

Expression across tissuesHPA

Tissue

  • midbrain: 2,060 nTPM
  • amygdala: 1,997 nTPM
  • basal ganglia: 1,974 nTPM
  • salivary gland: 1,954 nTPM
  • cerebral cortex: 1,731 nTPM
  • skeletal muscle: 1,708 nTPM

Single-cell type

  • bergmann glia: 797 nCPM
  • salivary acinar cells: 787 nCPM
  • esophageal apical cells: 730 nCPM
  • breast secretory cells: 532 nCPM
  • schwann cells: 504 nCPM
  • lacrimal acinar cells: 483 nCPM

Immune cell

  • myeloid DC: 205 nTPM
  • naive CD4 T-cell: 19 nTPM
  • total PBMC: 15 nTPM
  • naive CD8 T-cell: 14 nTPM
  • memory CD4 T-cell: 13 nTPM
  • memory CD8 T-cell: 12 nTPM

Brain region

  • basal ganglia: 1,656 nTPM
  • thalamus: 1,428 nTPM
  • medulla oblongata: 1,285 nTPM
  • midbrain: 1,269 nTPM
  • cerebellum: 1,122 nTPM
  • amygdala: 1,107 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.75
gnomAD pLI
0
gnomAD missense Z
0.62
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NDRG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NDRG2 as an antibody target. Whether an autoantibody or antibody against NDRG2 could matter depends on whether native NDRG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NDRG2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NDRG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NDRG2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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