Seroatlas · Human Serome Atlas

AJAP1

Adherens junction-associated protein 1

Also known as: AJAP1_HUMAN, MOT8, SHREW-1, SHREW1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UKB5
Gene
AJAP1
Ensembl
ENSG00000196581
Chromosome
1
Canonical length
411 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Enables beta-catenin binding activity. Involved in negative regulation of cell-matrix adhesion; negative regulation of wound healing; and regulation of polarized epithelial cell differentiation. Located in several cellular components, including adherens junction; basolateral plasma membrane; and cell-cell contact zone. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

411 residues, UniProt reviewed canonical sequence.

>Q9UKB5|AJAP1
     1  MWIQQLLGLS SMSIRWPGRP LGSHAWILIA MFQLAVDLPA CEALGPGPEF WLLPRSPPRP
    61  PRLWSFRSGQ PARVPAPVWS PRPPRVERIH GQMQMPRARR AHRPRDQAAA LVPKAGLAKP
   121  PAAAKSSPSL ASSSSSSSSA VAGGAPEQQA LLRRGKRHLQ GDGLSSFDSR GSRPTTETEF
   181  IAWGPTGDEE ALESNTFPGV YGPTTVSILQ TRKTTVAATT TTTTTATPMT LQTKGFTESL
   241  DPRRRIPGGV STTEPSTSPS NNGEVTQPPR ILGEASGLAV HQIITITVSL IMVIAALITT
   301  LVLKNCCAQS GNTRRNSHQR KTNQQEESCQ NLTDFPSARV PSSLDIFTAY NETLQCSHEC
   361  VRASVPVYTD ETLHSTTGEY KSTFNGNRPS SSDRHLIPVA FVSEKWFEIS C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AJAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.69
Highest tissue expression
6 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 6 nTPM
  • basal ganglia: 5.8 nTPM
  • hippocampal formation: 4.9 nTPM
  • amygdala: 3.9 nTPM
  • midbrain: 3.9 nTPM
  • ovary: 3.7 nTPM

Single-cell type

  • brain inhibitory neurons: 75 nCPM
  • oligodendrocyte progenitor cells: 75 nCPM
  • choroid plexus epithelial cells: 71 nCPM
  • other brain neurons: 56 nCPM
  • retinal bipolar cells: 56 nCPM
  • loop of henle epithelial cells: 56 nCPM

Immune cell

  • eosinophil: 1.8 nTPM
  • plasmacytoid DC: 0.7 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 58 nTPM
  • hippocampal formation: 57 nTPM
  • amygdala: 50 nTPM
  • basal ganglia: 48 nTPM
  • midbrain: 40 nTPM
  • white matter: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.19
gnomAD pLI
0.99
gnomAD missense Z
0.94
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AJAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AJAP1 as an antibody target. Whether an autoantibody or antibody against AJAP1 could matter depends on whether native AJAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AJAP1 is annotated at the cell surface, where native AJAP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label AJAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AJAP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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