Seroatlas · Human Serome Atlas

NANOS1

Nanos homolog 1

Also known as: NANO1_HUMAN, NOS1, ZC2HC12A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WY41
Gene
NANOS1
Ensembl
ENSG00000188613
Chromosome
10
Canonical length
292 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]

Canonical amino-acid sequenceUniProt

292 residues, UniProt reviewed canonical sequence.

>Q8WY41|NANOS1
     1  MEAFPWAPRS PRRGRAPPPM ALVPSARYVS APGPAHPQPF SSWNDYLGLA TLITKAVDGE
    61  PRFGCARGGN GGGGSPPSSS SSSCCSPHTG AGPGALGPAL GPPDYDEDDD DDSDEPGSRG
   121  RYLGSALELR ALELCAGPAE AGLLEERFAE LSPFAGRAAA VLLGCAPAAA AAATTTSEAT
   181  PREERAPAWA AEPRLHAASG AAAARLLKPE LQVCVFCRNN KEAMALYTTH ILKGPDGRVL
   241  CPVLRRYTCP LCGASGDNAH TIKYCPLSKV PPPPARPPPR SARDGPPGKK LR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NANOS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 36 nTPM
  • adrenal gland: 11 nTPM
  • heart muscle: 9.6 nTPM
  • adipose tissue: 8.7 nTPM
  • hypothalamus: 8.1 nTPM
  • breast: 7.7 nTPM

Single-cell type

  • retinal pigment epithelial cells: 21 nCPM
  • breast lactating cells: 18 nCPM
  • pancreatic islet cells: 18 nCPM
  • epididymal efferent duct ciliated cells: 13 nCPM
  • breast secretory cells: 11 nCPM
  • cone photoreceptor cells: 10 nCPM

Immune cell

  • basophil: 0.3 nTPM
  • neutrophil: 0.2 nTPM
  • eosinophil: 0.1 nTPM
  • NK-cell: 0.1 nTPM
  • plasmacytoid DC: 0.1 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • hypothalamus: 18 nTPM
  • white matter: 16 nTPM
  • midbrain: 13 nTPM
  • medulla oblongata: 12 nTPM
  • pons: 12 nTPM
  • basal ganglia: 8.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NANOS1.

Disease | AllUniProt

Conditions NANOS1 is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 91 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Spermatogenic failure 12

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.22
gnomAD pLI
0.54
gnomAD missense Z
1.2
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NANOS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NANOS1 as an antibody target. Whether an autoantibody or antibody against NANOS1 could matter depends on whether native NANOS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NANOS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NANOS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NANOS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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