Seroatlas · Human Serome Atlas

FBXO16

F-box only protein 16

Also known as: FBX16, FBX16_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IX29
Gene: FBXO16
Ensembl: ENSG00000214050
Chromosome: 8
Canonical length: 292 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Canonical amino-acid sequenceUniProt

292 residues, UniProt reviewed canonical sequence.

>Q8IX29|FBXO16
     1  MMAFAPPKNT DGPKMQTKMS TWTPLNHQLL NDRVFEERRA LLGKWFDKWT DSQRRRILTG
    61  LLERCSLSQQ KFCCRKLQEK IPAEALDFTT KLPRVLSLYI FSFLDPRSLC RCAQVCWHWK
   121  NLAELDQLWM LKCLRFNWYI NFSPTPFEQG IWKKHYIQMV KELHITKPKT PPKDGFVIAD
   181  VQLVTSNSPE EKQSPLSAFR SSSSLRKKNN SGEKALPPWR SSDKHPTDII RFNYLDNRDP
   241  METVQQGRRK RNQMTPDFSR QSHDKKNKLQ DRTRLRKAQS MMSRRNPFPL CP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXO16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

epididymis: 17 nTPM
pituitary gland: 17 nTPM
retina: 13 nTPM
choroid plexus: 8.4 nTPM
basal ganglia: 8 nTPM
cerebral cortex: 7.3 nTPM

Single-cell type

somatotrophs: 275 nCPM
lactotrophs: 265 nCPM
corticotrophs: 227 nCPM
thyrotrophs: 223 nCPM
gonadotrophs: 222 nCPM
rod photoreceptor cells: 194 nCPM

Immune cell

plasmacytoid DC: 8.8 nTPM
myeloid DC: 0.6 nTPM
neutrophil: 0.6 nTPM
basophil: 0.2 nTPM
MAIT T-cell: 0.2 nTPM
memory B-cell: 0.2 nTPM

Brain region

cerebellum: 26 nTPM
basal ganglia: 24 nTPM
cerebral cortex: 23 nTPM
white matter: 21 nTPM
hypothalamus: 21 nTPM
choroid plexus: 19 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FBXO16.

Disease | ImmuneIEDB

Conditions an epitope on FBXO16 was assayed in.

narcolepsy B cell
multiple sclerosis B cell
peripheral nervous system disease B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: -0.26
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Ubl conjugation pathway

InteractionsUniProt · HPA

Protein binding partners of FBXO16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXO16 as an antibody target. Whether an autoantibody or antibody against FBXO16 could matter depends on whether native FBXO16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXO16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXO16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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