Seroatlas · Human Serome Atlas

CTNNA3

Catenin alpha-3

Also known as: CTNA3_HUMAN, MGC26194, VR22

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UI47
Gene: CTNNA3
Ensembl: ENSG00000183230
Chromosome: 10
Canonical length: 895 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein that belongs to the vinculin/alpha-catenin family. The encoded protein plays a role in cell-cell adhesion in muscle cells. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia, familial 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Canonical amino-acid sequenceUniProt

895 residues, UniProt reviewed canonical sequence.

>Q9UI47|CTNNA3
     1  MSAETPITLN IDPQDLQVQT FTVEKLLEPL IIQVTTLVNC PQNPSSRKKG RSKRASVLLA
    61  SVEEATWNLL DKGEKIAQEA TVLKDELTAS LEEVRKESEA LKVSAERFTD DPCFLPKREA
   121  VVQAARALLA AVTRLLILAD MIDVMCLLQH VSAFQRTFES LKNVANKSDL QKTYQKLGKE
   181  LENLDYLAFK RQQDLKSPNQ RDEIAGARAS LKENSPLLHS ICSACLEHSD VASLKASKDT
   241  VCEEIQNALN VISNASQGIQ NMTTPPEPQA ATLGSALDEL ENLIVLNPLT VTEEEIRPSL
   301  EKRLEAIISG AALLADSSCT RDLHRERIIA ECNAIRQALQ DLLSEYMNNA GKKERSNTLN
   361  IALDNMCKKT RDLRRQLRKA IIDHVSDSFL DTTVPLLVLI EAAKNGREKE IKEYAAIFHE
   421  HTSRLVEVAN LACSMSTNED GIKIVKIAAN HLETLCPQII NAALALAARP KSQAVKNTME
   481  MYKRTWENHI HVLTEAVDDI TSIDDFLAVS ESHILEDVNK CIIALRDQDA DNLDRAAGAI
   541  RGRAARVAHI VTGEMDSYEP GAYTEGVMRN VNFLTSTVIP EFVTQVNVAL EALSKSSLNV
   601  LDDNQFVDIS KKIYDTIHDI RCSVMMIRTP EELEDVSDLE EEHEVRSHTS IQTEGKTDRA
   661  KMTQLPEAEK EKIAEQVADF KKVKSKLDAE IEIWDDTSND IIVLAKNMCM IMMEMTDFTR
   721  GKGPLKHTTD VIYAAKMISE SGSRMDVLAR QIANQCPDPS CKQDLLAYLE QIKFYSHQLK
   781  ICSQVKAEIQ NLGGELIMSA LDSVTSLIQA AKNLMNAVVQ TVKMSYIAST KIIRIQSPAG
   841  PRHPVVMWRM KAPAKKPLIK REKPEETCAA VRRGSAKKKI HPLQVMSEFR GRQIY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTNNA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

tongue: 14 nTPM
heart muscle: 14 nTPM
skeletal muscle: 3.9 nTPM
spinal cord: 2.7 nTPM
cerebral cortex: 2.3 nTPM
smooth muscle: 1.4 nTPM

Single-cell type

myonuclei: 5,423 nCPM
oligodendrocytes: 5,017 nCPM
cardiomyocytes: 3,863 nCPM
bergmann glia: 2,992 nCPM
sertoli cells: 797 nCPM
early spermatids: 611 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 141 nTPM
medulla oblongata: 97 nTPM
basal ganglia: 87 nTPM
pons: 65 nTPM
midbrain: 64 nTPM
spinal cord: 64 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CTNNA3.

Disease | AllUniProt

Conditions CTNNA3 is implicated in, by any mechanism.

Arrhythmogenic right ventricular dysplasia, familial, 13 (ARVD13) MIM:615616

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 1,229 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Arrhythmogenic right ventricular dysplasia 13
Arrhythmogenic right ventricular cardiomyopathy
Malignant tumor of urinary bladder
Long QT syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0
gnomAD missense Z: -1.11
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CTNNA3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTNNA3 as an antibody target. Whether an autoantibody or antibody against CTNNA3 could matter depends on whether native CTNNA3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTNNA3 is annotated at the cell surface, where native CTNNA3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CTNNA3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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