Seroatlas · Human Serome Atlas

EPB41L2

Band 4.1-like protein 2

Also known as: 4.1-G, 4.1G, E41L2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43491
Gene
EPB41L2
Ensembl
ENSG00000079819
Chromosome
6
Canonical length
1005 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cell Junctions

OverviewNCBI Gene

Predicted to enable PH domain binding activity; cytoskeletal protein binding activity; and structural molecule activity. Involved in positive regulation of protein localization to cell cortex. Located in several cellular components, including cell cortex; cell junction; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1005 residues, UniProt reviewed canonical sequence.

>O43491|EPB41L2
     1  MTTEVGSVSE VKKDSSQLGT DATKEKPKEV AENQQNQSSD PEEEKGSQPP PAAESQSSLR
    61  RQKREKETSE SRGISRFIPP WLKKQKSYTL VVAKDGGDKK EPTQAVVEEQ VLDKEEPLPE
   121  EQRQAKGDAE EMAQKKQEIK VEVKEEKPSV SKEEKPSVSK VEMQPTELVS KEREEKVKET
   181  QEDKLEGGAA KRETKEVQTN ELKAEKASQK VTKKTKTVQC KVTLLDGTEY SCDLEKHAKG
   241  QVLFDKVCEH LNLLEKDYFG LLFQESPEQK NWLDPAKEIK RQLRNLPWLF TFNVKFYPPD
   301  PSQLTEDITR YFLCLQLRQD IASGRLPCSF VTHALLGSYT LQAELGDYDP EEHGSIDLSE
   361  FQFAPTQTKE LEEKVAELHK THRGLSPAQA DSQFLENAKR LSMYGVDLHH AKDSEGVDIK
   421  LGVCANGLLI YKDRLRINRF AWPKILKISY KRSNFYIKVR PAELEQFEST IGFKLPNHRA
   481  AKRLWKVCVE HHTFYRLVSP EQPPKAKFLT LGSKFRYSGR TQAQTRQAST LIDRPAPHFE
   541  RTSSKRVSRS LDGAPIGVMD QSLMKDFPGA AGEISAYGPG LVSIAVVQDG DGRREVRSPT
   601  KAPHLQLIEG KKNSLRVEGD NIYVRHSNLM LEELDKAQED ILKHQASISE LKRNFMESTP
   661  EPRPNEWEKR RITPLSLQTQ GSSHETLNIV EEKKRAEVGK DERVITEEMN GKEISPGSGP
   721  GEIRKVEPVT QKDSTSLSSE SSSSSSESEE EDVGEYRPHH RVTEGTIREE QEYEEEVEEE
   781  PRPAAKVVER EEAVPEASPV TQAGASVITV ETVIQENVGA QKIPGEKSVH EGALKQDMGE
   841  EAEEEPQKVN GEVSHVDIDV LPQIICCSEP PVVKTEMVTI SDASQRTEIS TKEVPIVQTE
   901  TKTITYESPQ IDGGAGGDSG TLLTAQTITS ESVSTTTTTH ITKTVKGGIS ETRIEKRIVI
   961  TGDGDIDHDQ ALAQAIREAR EQHPDMSVTR VVVHKETELA EEGED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EPB41L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
328 nTPM

Expression across tissuesHPA

Tissue

  • retina: 328 nTPM
  • spinal cord: 133 nTPM
  • adipose tissue: 102 nTPM
  • midbrain: 94 nTPM
  • ovary: 77 nTPM
  • cerebral cortex: 76 nTPM

Single-cell type

  • rod photoreceptor cells: 2,299 nCPM
  • microglia: 1,813 nCPM
  • müller glia: 869 nCPM
  • kupffer cells: 806 nCPM
  • cone photoreceptor cells: 727 nCPM
  • fibro-adipogenic progenitors: 694 nCPM

Immune cell

  • naive B-cell: 8.5 nTPM
  • myeloid DC: 8.2 nTPM
  • intermediate monocyte: 8 nTPM
  • non-classical monocyte: 3.3 nTPM
  • classical monocyte: 2.9 nTPM
  • T-reg: 2.6 nTPM

Brain region

  • white matter: 300 nTPM
  • basal ganglia: 289 nTPM
  • medulla oblongata: 277 nTPM
  • pons: 232 nTPM
  • cerebral cortex: 214 nTPM
  • thalamus: 209 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.99
gnomAD missense Z
0.69
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EPB41L2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EPB41L2 as an antibody target. Whether an autoantibody or antibody against EPB41L2 could matter depends on whether native EPB41L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EPB41L2 is annotated at the cell surface, where native EPB41L2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label EPB41L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EPB41L2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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