Seroatlas · Human Serome Atlas

LSM10

U7 snRNA-associated Sm-like protein LSm10

Also known as: LSM10_HUMAN, MGC15749

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q969L4
Gene: LSM10
Ensembl: ENSG00000181817
Chromosome: 1
Canonical length: 123 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Enables U7 snRNA binding activity. Involved in positive regulation of G1/S transition of mitotic cell cycle. Located in Cajal body. Part of U7 snRNP. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

123 residues, UniProt reviewed canonical sequence.

>Q969L4|LSM10
     1  MAVSHSVKER TISENSLIIL LQGLQGRVTT VDLRDESVAH GRIDNVDAFM NIRLAKVTYT
    61  DRWGHQVKLD DLFVTGRNVR YVHIPDDVNI TSTIEQQLQI IHRVRNFGGK GQGRWEFPPK
   121  NCK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LSM10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 157 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 157 nTPM
tongue: 103 nTPM
heart muscle: 68 nTPM
colon: 58 nTPM
spleen: 52 nTPM
choroid plexus: 52 nTPM

Single-cell type

hofbauer cells: 134 nCPM
megakaryocytes: 99 nCPM
esophageal basal cells: 91 nCPM
esophageal suprabasal cells: 89 nCPM
plasma cells: 89 nCPM
decidual stromal cells: 85 nCPM

Immune cell

naive B-cell: 390 nTPM
memory B-cell: 388 nTPM
neutrophil: 348 nTPM
eosinophil: 341 nTPM
total PBMC: 302 nTPM
intermediate monocyte: 267 nTPM

Brain region

hypothalamus: 37 nTPM
thalamus: 33 nTPM
pons: 30 nTPM
midbrain: 30 nTPM
spinal cord: 30 nTPM
choroid plexus: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: 0.47
DepMap mean gene effect: -0.56
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Cajal body
nuclear body
nucleoplasm
U7 snRNP
cytoplasmic U snRNP body

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LSM10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LSM10 as an antibody target. Whether an autoantibody or antibody against LSM10 could matter depends on whether native LSM10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LSM10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LSM10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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