Seroatlas · Human Serome Atlas

NR1D1

Nuclear receptor subfamily 1 group D member 1

Also known as: ear-1, hRev, NR1D1_HUMAN, Rev-ErbAalpha, REVERBA, REVERBalpha, THRA1, THRAL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P20393
Gene
NR1D1
Ensembl
ENSG00000126368
Chromosome
17
Canonical length
614 aa
Protein class
Metabolic proteins, Nuclear receptors, Predicted intracellular proteins, Transcription factors
Subcellular location
Nuclear bodies
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Jan 2013]

Canonical amino-acid sequenceUniProt

614 residues, UniProt reviewed canonical sequence.

>P20393|NR1D1
     1  MTTLDSNNNT GGVITYIGSS GSSPSRTSPE SLYSDNSNGS FQSLTQGCPT YFPPSPTGSL
    61  TQDPARSFGS IPPSLSDDGS PSSSSSSSSS SSSFYNGSPP GSLQVAMEDS SRVSPSKSTS
   121  NITKLNGMVL LCKVCGDVAS GFHYGVHACE GCKGFFRRSI QQNIQYKRCL KNENCSIVRI
   181  NRNRCQQCRF KKCLSVGMSR DAVRFGRIPK REKQRMLAEM QSAMNLANNQ LSSQCPLETS
   241  PTQHPTPGPM GPSPPPAPVP SPLVGFSQFP QQLTPPRSPS PEPTVEDVIS QVARAHREIF
   301  TYAHDKLGSS PGNFNANHAS GSPPATTPHR WENQGCPPAP NDNNTLAAQR HNEALNGLRQ
   361  APSSYPPTWP PGPAHHSCHQ SNSNGHRLCP THVYAAPEGK APANSPRQGN SKNVLLACPM
   421  NMYPHGRSGR TVQEIWEDFS MSFTPAVREV VEFAKHIPGF RDLSQHDQVT LLKAGTFEVL
   481  MVRFASLFNV KDQTVMFLSR TTYSLQELGA MGMGDLLSAM FDFSEKLNSL ALTEEELGLF
   541  TAVVLVSADR SGMENSASVE QLQETLLRAL RALVLKNRPL ETSRFTKLLL KLPDLRTLNN
   601  MHSEKLLSFR VDAQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NR1D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
329 nTPM

Expression across tissuesHPA

Tissue

  • skin: 329 nTPM
  • skeletal muscle: 100 nTPM
  • vagina: 99 nTPM
  • cervix: 91 nTPM
  • cerebellum: 80 nTPM
  • blood vessel: 80 nTPM

Single-cell type

  • ocular epithelial cells: 169 nCPM
  • esophageal apical cells: 147 nCPM
  • epididymal efferent duct absorptive cells: 146 nCPM
  • oocytes: 111 nCPM
  • endometrial glandular cells: 102 nCPM
  • pancreatic acinar cells: 78 nCPM

Immune cell

  • MAIT T-cell: 19 nTPM
  • T-reg: 8 nTPM
  • memory CD8 T-cell: 6.4 nTPM
  • non-classical monocyte: 5.6 nTPM
  • memory CD4 T-cell: 5.5 nTPM
  • naive CD4 T-cell: 4.9 nTPM

Brain region

  • cerebellum: 118 nTPM
  • cerebral cortex: 111 nTPM
  • thalamus: 82 nTPM
  • basal ganglia: 65 nTPM
  • white matter: 60 nTPM
  • amygdala: 58 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.82
gnomAD missense Z
1.38
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NR1D1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NR1D1 as an antibody target. Whether an autoantibody or antibody against NR1D1 could matter depends on whether native NR1D1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NR1D1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NR1D1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NR1D1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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