RGCC
Regulator of cell cycle RGCC
Also known as: bA157L14.2, C13orf15, RGC-32, RGC32, RGCC_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H4X1
- Gene
- RGCC
- Ensembl
- ENSG00000102760
- Chromosome
- 13
- Canonical length
- 137 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nucleoli
OverviewNCBI Gene
This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
137 residues, UniProt reviewed canonical sequence.
>Q9H4X1|RGCC
1 MKPPAAQGSP AAAAAAAPAL DSAAAEDLSD ALCEFDAVLA DFASPFHERH FHYEEHLERM
61 KRRSSASVSD SSGFSDSESA DSLYRNSFSF SDEKLNSPTD STPALLSATV TPQKAKLGDT
121 KELEAFIADL DKTLASMLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RGCC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.63
- Highest tissue expression
- 668 nTPM
Expression across tissuesHPA
Tissue
- lung: 668 nTPM
- bone marrow: 392 nTPM
- adipose tissue: 185 nTPM
- hippocampal formation: 172 nTPM
- midbrain: 150 nTPM
- basal ganglia: 148 nTPM
Single-cell type
- breast lactating cells: 544 nCPM
- breast secretory cells: 543 nCPM
- schwann cells: 509 nCPM
- bergmann glia: 483 nCPM
- neutrophil progenitors: 440 nCPM
- vascular endothelial cells: 439 nCPM
Immune cell
- naive CD4 T-cell: 161 nTPM
- T-reg: 91 nTPM
- memory CD4 T-cell: 47 nTPM
- naive CD8 T-cell: 35 nTPM
- memory CD8 T-cell: 15 nTPM
- naive B-cell: 11 nTPM
Brain region
- white matter: 227 nTPM
- basal ganglia: 203 nTPM
- cerebellum: 189 nTPM
- medulla oblongata: 168 nTPM
- cerebral cortex: 165 nTPM
- pons: 162 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.52
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.7
- DepMap mean gene effect
- 0.05
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cellular response to hypoxia
- complement receptor mediated signaling pathway
- fibroblast activation
- negative regulation of angiogenesis
- negative regulation of blood vessel endothelial cell migration
- negative regulation of cell population proliferation
- negative regulation of cell-cell adhesion mediated by cadherin
- negative regulation of cytokine production
- negative regulation of endothelial cell proliferation
- negative regulation of fibroblast growth factor production
- negative regulation of mitotic cell cycle phase transition
- phosphatidylinositol 3-kinase/protein kinase B signal transduction
- positive regulation of collagen biosynthetic process
- positive regulation of cytokine production
- positive regulation of endothelial cell apoptotic process
- positive regulation of epithelial to mesenchymal transition
- positive regulation of extracellular matrix assembly
- positive regulation of extracellular matrix constituent secretion
- positive regulation of G1/S transition of mitotic cell cycle
- positive regulation of gene expression
- positive regulation of mitotic cell cycle
- positive regulation of stress fiber assembly
- positive regulation of transcription by RNA polymerase II
- positive regulation of vascular associated smooth muscle cell proliferation
- transforming growth factor beta receptor signaling pathway
- negative regulation of exit from mitosis
Molecular functions
- kinase activator activity
- protein kinase activator activity
- protein kinase binding
- protein kinase regulator activity
- R-SMAD binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Regulator of cell cycle RGCC
- Response gene to complement 32 protein family
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of RGCC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RGCC as an antibody target. Whether an autoantibody or antibody against RGCC could matter depends on whether native RGCC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RGCC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RGCC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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