Seroatlas · Human Serome Atlas

HMGN5

High mobility group nucleosome-binding domain-containing protein 5

Also known as: HMGN5_HUMAN, NSBP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P82970
Gene: HMGN5
Ensembl: ENSG00000198157
Chromosome: X
Canonical length: 282 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

This gene encodes a nuclear protein with similarities to the high mobility group proteins, HMG14 and HMG17, which suggests that this protein may function as a nucleosomal binding and transcriptional activating protein. [provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

282 residues, UniProt reviewed canonical sequence.

>P82970|HMGN5
     1  MPKRKAAGQG DMRQEPKRRS ARLSAMLVPV TPEVKPKRTS SSRKMKTKSD MMEENIDTSA
    61  QAVAETKQEA VVEEDYNENA KNGEAKITEA PASEKEIVEV KEENIEDATE KGGEKKEAVA
   121  AEVKNEEEDQ KEDEEDQNEE KGEAGKEDKD EKGEEDGKED KNGNEKGEDA KEKEDGKKGE
   181  DGKGNGEDGK EKGEDEKEEE DRKETGDGKE NEDGKEKGDK KEGKDVKVKE DEKEREDGKE
   241  DEGGNEEEAG KEKEDLKEEE EGKEEDEIKE DDGKKEEPQS IV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HMGN5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.74
Highest tissue expression: 100 nTPM

Expression across tissuesHPA

Tissue

testis: 100 nTPM
epididymis: 62 nTPM
spinal cord: 40 nTPM
choroid plexus: 38 nTPM
hypothalamus: 34 nTPM
midbrain: 33 nTPM

Single-cell type

sertoli cells: 410 nCPM
epididymal principal cells: 214 nCPM
epididymal efferent duct ciliated cells: 168 nCPM
erythrocyte progenitors: 157 nCPM
oocytes: 115 nCPM
respiratory ciliated cells: 108 nCPM

Immune cell

plasmacytoid DC: 10 nTPM
naive CD4 T-cell: 8.7 nTPM
gdT-cell: 7.6 nTPM
naive CD8 T-cell: 7.6 nTPM
MAIT T-cell: 6.6 nTPM
naive B-cell: 6.1 nTPM

Brain region

medulla oblongata: 36 nTPM
thalamus: 31 nTPM
white matter: 31 nTPM
midbrain: 30 nTPM
pons: 30 nTPM
spinal cord: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0.31
gnomAD missense Z: -0.15
DepMap mean gene effect: 0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

High mobility group protein HMGN
HMG14 and HMG17
High mobility group nucleosome-binding domain-containing protein 5

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HMGN5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CBX8

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HMGN5 as an antibody target. Whether an autoantibody or antibody against HMGN5 could matter depends on whether native HMGN5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HMGN5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HMGN5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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