Guanine-nucleotide dissociation stimulator, CDC24, conserved site
IPR001331
Definition
Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP PMID:1898771. The balance between the GTP bound (active) and GDP bound (inactive) states is regulated by the opposite action of proteins activating the GTPase activity and that of proteins which promote the loss of bound GDP and the uptake of fresh GTP [[cite:PMID:8259209], [cite:PMID:15335949]]. The latter proteins are known as guanine-nucleotide dissociation stimulators (GDSs) or also as guanine-nucleotide releasing (or exchange) factors (GRFs). Proteins that act as GDS can be classified into at least two families. One of these families is currently known to group the CDC24 family of proteins.
21 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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