PIP5K1B

Protein identityUniProt · HPA

UniProt accession

O14986

Gene

PIP5K1B

Ensembl

ENSG00000107242

Chromosome

9

Canonical length

540 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process. Predicted to act upstream of or within phosphatidylinositol biosynthetic process. Located in uropod. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

540 residues, UniProt reviewed canonical sequence.

>O14986|PIP5K1B
     1  MSSAAENGEA APGKQNEEKT YKKTASSAIK GAIQLGIGYT VGNLTSKPER DVLMQDFYVV
    61  ESVFLPSEGS NLTPAHHYPD FRFKTYAPLA FRYFRELFGI KPDDYLYSIC SEPLIELSNP
   121  GASGSLFFVT SDDEFIIKTV QHKEAEFLQK LLPGYYMNLN QNPRTLLPKF YGLYCMQSGG
   181  INIRIVVMNN VLPRSMRMHF TYDLKGSTYK RRASRKEREK SNPTFKDLDF LQDMHEGLYF
   241  DTETYNALMK TLQRDCRVLE SFKIMDYSLL LGIHFLDHSL KEKEEETPQN VPDAKRTGMQ
   301  KVLYSTAMES IQGPGKSGDG IITENPDTMG GIPAKSHRGE KLLLFMGIID ILQSYRLMKK
   361  LEHSWKALVY DGDTVSVHRP SFYADRFLKF MNSRVFKKIQ ALKASPSKKR CNSIAALKAT
   421  SQEIVSSISQ EWKDEKRDLL TEGQSFSSLD EEALGSRHRP DLVPSTPSLF EAASLATTIS
   481  SSSLYVNEHY PHDRPTLYSN SKGLPSSSTF TLEEGTIYLT AEPNTLEVQD DNASVLDVYL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIP5K1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.41

Highest tissue expression

111 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PIP5K1B.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 70 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Familial hypercholesterolemia

Disease | ImmuneIEDB

Conditions an epitope on PIP5K1B was assayed in.

• narcolepsy B cell
• multiple sclerosis B cell
• peripheral nervous system disease B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.81

gnomAD pLI

0

gnomAD missense Z

2.48

DepMap mean gene effect

0.13

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• phosphatidylinositol biosynthetic process
• phosphatidylinositol phosphate biosynthetic process
• regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

Molecular functions

• 1-phosphatidylinositol-3-phosphate 5-kinase activity
• 1-phosphatidylinositol-4-phosphate 5-kinase activity
• 1-phosphatidylinositol-5-kinase activity
• ATP binding
• phosphatidylinositol kinase activity

Cellular components

• cytosol
• endomembrane system
• plasma membrane
• uropod

Protein domainsUniProt · Pfam · InterPro

• Phosphatidylinositol-4-phosphate 4/5-kinase, core
• Phosphatidylinositol-4/5-phosphate 5/4-kinase
• Phosphatidylinositol-4-phosphate 4/5-kinase, C-terminal domain superfamily
• Phosphatidylinositol-4-phosphate 5-kinase, N-terminal
• Phosphatidylinositol-4-phosphate 5-Kinase

KeywordsUniProt

• ATP-binding
• Cell membrane
• Cytoplasm
• Kinase
• Lipid metabolism
• Membrane
• Nucleotide-binding
• Phosphoprotein
• Transferase

InteractionsUniProt · HPA

Protein binding partners of PIP5K1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• AJUBA
• ARF1
• PLD1
• PLD2
• RAC1