Seroatlas · Human Serome Atlas

PLEKHA8

Pleckstrin homology domain-containing family A member 8

Also known as: FAPP2, MGC3358, PKHA8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96JA3
Gene: PLEKHA8
Ensembl: ENSG00000106086
Chromosome: 7
Canonical length: 519 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables several functions, including ceramide binding activity; glycolipid transfer activity; and phosphatidylinositol-4-phosphate binding activity. Involved in ER to Golgi ceramide transport. Located in nucleoplasm and trans-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

519 residues, UniProt reviewed canonical sequence.

>Q96JA3|PLEKHA8
     1  MEGVLYKWTN YLSGWQPRWF LLCGGILSYY DSPEDAWKGC KGSIQMAVCE IQVHSVDNTR
    61  MDLIIPGEQY FYLKARSVAE RQRWLVALGS AKACLTDSRT QKEKEFAENT ENLKTKMSEL
   121  RLYCDLLVQQ VDKTKEVTTT GVSNSEEGID VGTLLKSTCN TFLKTLEECM QIANAAFTSE
   181  LLYRTPPGSP QLAMLKSSKM KHPIIPIHNS LERQMELSTC ENGSLNMEIN GEEEILMKNK
   241  NSLYLKSAEI DCSISSEENT DDNITVQGEI RKEDGMENLK NHDNNLTQSG SDSSCSPECL
   301  WEEGKEVIPT FFSTMNTSFS DIELLEDSGI PTEAFLASCY AVVPVLDKLG PTVFAPVKMD
   361  LVGNIKKVNQ KYITNKEEFT TLQKIVLHEV EADVAQVRNS ATEALLWLKR GLKFLKGFLT
   421  EVKNGEKDIQ TALNNAYGKT LRQHHGWVVR GVFALALRAA PSYEDFVAAL TVKEGDHQKE
   481  AFSIGMQRDL SLYLPAMEKQ LAILDTLYEV HGLESDEVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLEKHA8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

retina: 11 nTPM
placenta: 7.5 nTPM
cerebellum: 5.7 nTPM
kidney: 5.7 nTPM
tonsil: 4.4 nTPM
blood vessel: 4.3 nTPM

Single-cell type

renal collecting duct intercalated cells: 112 nCPM
bergmann glia: 75 nCPM
cone photoreceptor cells: 62 nCPM
astrocytes: 56 nCPM
endometrial glandular cells: 53 nCPM
syncytiotrophoblasts: 51 nCPM

Immune cell

eosinophil: 0.5 nTPM
basophil: 0.3 nTPM
gdT-cell: 0.3 nTPM
naive CD8 T-cell: 0.3 nTPM
memory B-cell: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM

Brain region

cerebellum: 12 nTPM
cerebral cortex: 9.9 nTPM
medulla oblongata: 9.7 nTPM
white matter: 9.6 nTPM
thalamus: 9.4 nTPM
amygdala: 8.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0
gnomAD missense Z: 0.94
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLEKHA8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ARF1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLEKHA8 as an antibody target. Whether an autoantibody or antibody against PLEKHA8 could matter depends on whether native PLEKHA8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLEKHA8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLEKHA8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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