Seroatlas · Human Serome Atlas

NCS1

Neuronal calcium sensor 1

Also known as: FREQ, NCS-1, NCS1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P62166
Gene: NCS1
Ensembl: ENSG00000107130
Chromosome: 9
Canonical length: 190 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Plasma membrane

OverviewNCBI Gene

This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

190 residues, UniProt reviewed canonical sequence.

>P62166|NCS1
     1  MGKSNSKLKP EVVEELTRKT YFTEKEVQQW YKGFIKDCPS GQLDAAGFQK IYKQFFPFGD
    61  PTKFATFVFN VFDENKDGRI EFSEFIQALS VTSRGTLDEK LRWAFKLYDL DNDGYITRNE
   121  MLDIVDAIYQ MVGNTVELPE EENTPEKRVD RIFAMMDKNA DGKLTLQEFQ EGSKADPSIV
   181  QALSLYDGLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NCS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 357 nTPM

Expression across tissuesHPA

Tissue

hippocampal formation: 357 nTPM
cerebral cortex: 325 nTPM
amygdala: 320 nTPM
basal ganglia: 227 nTPM
colon: 112 nTPM
hypothalamus: 105 nTPM

Single-cell type

smooth muscle cells: 151 nCPM
retinal horizontal cells: 70 nCPM
retinal amacrine cells: 69 nCPM
vascular smooth muscle cells: 66 nCPM
proximal tubule cells: 65 nCPM
brain excitatory neurons: 63 nCPM

Immune cell

gdT-cell: 0.1 nTPM
MAIT T-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

hippocampal formation: 822 nTPM
cerebral cortex: 727 nTPM
amygdala: 640 nTPM
white matter: 423 nTPM
basal ganglia: 417 nTPM
thalamus: 414 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.52
gnomAD pLI: 0.66
gnomAD missense Z: 2.22
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NCS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NCS1 as an antibody target. Whether an autoantibody or antibody against NCS1 could matter depends on whether native NCS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NCS1 is annotated at the cell surface, where native NCS1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NCS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...