Seroatlas · Human Serome Atlas

SMAP2

Stromal membrane-associated protein 2

Also known as: SMAP1L, SMAP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WU79
Gene: SMAP2
Ensembl: ENSG00000084070
Chromosome: 1
Canonical length: 429 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable GTPase activator activity. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

429 residues, UniProt reviewed canonical sequence.

>Q8WU79|SMAP2
     1  MTGKSVKDVD RYQAVLANLL LEEDNKFCAD CQSKGPRWAS WNIGVFICIR CAGIHRNLGV
    61  HISRVKSVNL DQWTQEQIQC MQEMGNGKAN RLYEAYLPET FRRPQIDPAV EGFIRDKYEK
   121  KKYMDRSLDI NAFRKEKDDK WKRGSEPVPE KKLEPVVFEK VKMPQKKEDP QLPRKSSPKS
   181  TAPVMDLLGL DAPVACSIAN SKTSNTLEKD LDLLASVPSP SSSGSRKVVG SMPTAGSAGS
   241  VPENLNLFPE PGSKSEEIGK KQLSKDSILS LYGSQTPQMP TQAMFMAPAQ MAYPTAYPSF
   301  PGVTPPNSIM GSMMPPPVGM VAQPGASGMV APMAMPAGYM GGMQASMMGV PNGMMTTQQA
   361  GYMAGMAAMP QTVYGVQPAQ QLQWNLTQMT QQMAGMNFYG ANGMMNYGQS MSGGNGQAAN
   421  QTLSPQMWK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 208 nTPM

Expression across tissuesHPA

Tissue

spleen: 208 nTPM
lymph node: 193 nTPM
tonsil: 187 nTPM
thymus: 148 nTPM
appendix: 129 nTPM
small intestine: 93 nTPM

Single-cell type

neutrophils: 4,946 nCPM
b-cells: 1,106 nCPM
plasma cells: 974 nCPM
innate lymphoid cells: 930 nCPM
monocytes: 791 nCPM
neutrophil progenitors: 704 nCPM

Immune cell

non-classical monocyte: 197 nTPM
neutrophil: 196 nTPM
intermediate monocyte: 154 nTPM
eosinophil: 102 nTPM
classical monocyte: 88 nTPM
naive B-cell: 59 nTPM

Brain region

cerebral cortex: 92 nTPM
basal ganglia: 86 nTPM
hypothalamus: 83 nTPM
white matter: 81 nTPM
hippocampal formation: 78 nTPM
pons: 73 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.55
gnomAD pLI: 0.02
gnomAD missense Z: 1.52
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SMAP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMAP2 as an antibody target. Whether an autoantibody or antibody against SMAP2 could matter depends on whether native SMAP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMAP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMAP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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