Seroatlas · Human Serome Atlas

SMARCD2

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

Also known as: BAF60B, CRACD2, PRO2451, Rsc6p, SMRD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92925
Gene
SMARCD2
Ensembl
ENSG00000108604
Chromosome
17
Canonical length
531 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

531 residues, UniProt reviewed canonical sequence.

>Q92925|SMARCD2
     1  MSGRGAGGFP LPPLSPGGGA VAAALGAPPP PAGPGMLPGP ALRGPGPAGG VGGPGAAAFR
    61  PMGPAGPAAQ YQRPGMSPGN RMPMAGLQVG PPAGSPFGAA APLRPGMPPT MMDPFRKRLL
   121  VPQAQPPMPA QRRGLKRRKM ADKVLPQRIR ELVPESQAYM DLLAFERKLD QTIARKRMEI
   181  QEAIKKPLTQ KRKLRIYISN TFSPSKAEGD SAGTAGTPGG TPAGDKVASW ELRVEGKLLD
   241  DPSKQKRKFS SFFKSLVIEL DKELYGPDNH LVEWHRMPTT QETDGFQVKR PGDLNVKCTL
   301  LLMLDHQPPQ YKLDPRLARL LGVHTQTRAA IMQALWLYIK HNQLQDGHER EYINCNRYFR
   361  QIFSCGRLRF SEIPMKLAGL LQHPDPIVIN HVISVDPNDQ KKTACYDIDV EVDDPLKAQM
   421  SNFLASTTNQ QEIASLDVKI HETIESINQL KTQRDFMLSF STDPQDFIQE WLRSQRRDLK
   481  IITDVIGNPE EERRAAFYHQ PWAQEAVGRH IFAKVQQRRQ ELEQVLGIRL T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMARCD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
91 nTPM

Expression across tissuesHPA

Tissue

  • skin: 91 nTPM
  • pancreas: 81 nTPM
  • salivary gland: 69 nTPM
  • esophagus: 68 nTPM
  • stomach: 64 nTPM
  • thymus: 63 nTPM

Single-cell type

  • hepatocytes: 97 nCPM
  • breast lactating cells: 80 nCPM
  • monocyte progenitors: 74 nCPM
  • esophageal basal cells: 73 nCPM
  • lacrimal acinar cells: 73 nCPM
  • cytotrophoblasts: 71 nCPM

Immune cell

  • myeloid DC: 8.2 nTPM
  • neutrophil: 6.9 nTPM
  • classical monocyte: 6.6 nTPM
  • memory CD8 T-cell: 6.2 nTPM
  • gdT-cell: 6 nTPM
  • non-classical monocyte: 5.7 nTPM

Brain region

  • cerebellum: 38 nTPM
  • white matter: 33 nTPM
  • choroid plexus: 32 nTPM
  • medulla oblongata: 29 nTPM
  • basal ganglia: 29 nTPM
  • midbrain: 27 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SMARCD2.

Disease | AllUniProt

Conditions SMARCD2 is implicated in, by any mechanism.

Disease | GeneticClinVar

28 pathogenic / likely-pathogenic of 419 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.63
gnomAD pLI
0
gnomAD missense Z
2.22
DepMap mean gene effect
-0.2
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SMARCD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMARCD2 as an antibody target. Whether an autoantibody or antibody against SMARCD2 could matter depends on whether native SMARCD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMARCD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMARCD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMARCD2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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