Seroatlas · Human Serome Atlas

SMARCE1

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

Also known as: BAF57, SMCE1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q969G3
Gene
SMARCE1
Ensembl
ENSG00000073584
Chromosome
17
Canonical length
411 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

411 residues, UniProt reviewed canonical sequence.

>Q969G3|SMARCE1
     1  MSKRPSYAPP PTPAPATQMP STPGFVGYNP YSHLAYNNYR LGGNPGTNSR VTASSGITIP
    61  KPPKPPDKPL MPYMRYSRKV WDQVKASNPD LKLWEIGKII GGMWRDLTDE EKQEYLNEYE
   121  AEKIEYNESM KAYHNSPAYL AYINAKSRAE AALEEESRQR QSRMEKGEPY MSIQPAEDPD
   181  DYDDGFSMKH TATARFQRNH RLISEILSES VVPDVRSVVT TARMQVLKRQ VQSLMVHQRK
   241  LEAELLQIEE RHQEKKRKFL ESTDSFNNEL KRLCGLKVEV DMEKIAAEIA QAEEQARKRQ
   301  EEREKEAAEQ AERSQSSIVP EEEQAANKGE EKKDDENIPM ETEETHLEET TESQQNGEEG
   361  TSTPEDKESG QEGVDSMAEE GTSDSNTGSE SNSATVEEPP TDPIPEDEKK E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMARCE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
71 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 71 nTPM
  • ovary: 64 nTPM
  • smooth muscle: 54 nTPM
  • endometrium: 53 nTPM
  • tonsil: 51 nTPM
  • lymph node: 46 nTPM

Single-cell type

  • megakaryocytes: 50 nCPM
  • fallopian secretory cells: 31 nCPM
  • thymic myoid cells: 30 nCPM
  • fallopian tube ciliated cells: 28 nCPM
  • megakaryocyte progenitors: 27 nCPM
  • ocular epithelial cells: 26 nCPM

Immune cell

  • NK-cell: 125 nTPM
  • T-reg: 115 nTPM
  • naive B-cell: 113 nTPM
  • total PBMC: 112 nTPM
  • basophil: 107 nTPM
  • memory B-cell: 100 nTPM

Brain region

  • white matter: 37 nTPM
  • choroid plexus: 33 nTPM
  • medulla oblongata: 33 nTPM
  • cerebral cortex: 32 nTPM
  • hypothalamus: 29 nTPM
  • spinal cord: 28 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SMARCE1.

Disease | AllUniProt

Conditions SMARCE1 is implicated in, by any mechanism.

Disease | GeneticClinVar

78 pathogenic / likely-pathogenic of 1,187 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.19
gnomAD pLI
1
gnomAD missense Z
2.74
DepMap mean gene effect
-0.77
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SMARCE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMARCE1 as an antibody target. Whether an autoantibody or antibody against SMARCE1 could matter depends on whether native SMARCE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMARCE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMARCE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMARCE1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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