Seroatlas · Human Serome Atlas

MORF4L1

Mortality factor 4-like protein 1

Also known as: Eaf3, HsT17725, MEAF3, MO4L1_HUMAN, MORFRG15, MRG15

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UBU8
Gene: MORF4L1
Ensembl: ENSG00000185787
Chromosome: 15
Canonical length: 362 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Predicted to enable chromatin binding activity. Involved in double-strand break repair via homologous recombination; positive regulation of double-strand break repair via homologous recombination; and regulation of cell cycle. Located in nuclear speck. Part of NuA4 histone acetyltransferase complex; Sin3-type complex; and nucleosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

362 residues, UniProt reviewed canonical sequence.

>Q9UBU8|MORF4L1
     1  MAPKQDPKPK FQEGERVLCF HGPLLYEAKC VKVAIKDKQV KYFIHYSGWN KKSAVRPRRS
    61  EKSLKTHEDI VALFPVPEGA PSVHHPLLTS SWDEWVPESR VLKYVDTNLQ KQRELQKANQ
   121  EQYAEGKMRG AAPGKKTSGL QQKNVEVKTK KNKQKTPGNG DGGSTSETPQ PPRKKRARVD
   181  PTVENEETFM NRVEVKVKIP EELKPWLVDD WDLITRQKQL FYLPAKKNVD SILEDYANYK
   241  KSRGNTDNKE YAVNEVVAGI KEYFNVMLGT QLLYKFERPQ YAEILADHPD APMSQVYGAP
   301  HLLRLFVRIG AMLAYTPLDE KSLALLLNYL HDFLKYLAKN SATLFSASDY EVAPPEYHRK
   361  AV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MORF4L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 550 nTPM

Expression across tissuesHPA

Tissue

testis: 550 nTPM
skeletal muscle: 524 nTPM
bone marrow: 404 nTPM
tongue: 397 nTPM
blood vessel: 376 nTPM
heart muscle: 373 nTPM

Single-cell type

late primary spermatocytes: 2,195 nCPM
extravillous trophoblasts: 1,110 nCPM
migrating cytotrophoblasts: 788 nCPM
oocytes: 783 nCPM
early primary spermatocytes: 745 nCPM
syncytiotrophoblasts: 745 nCPM

Immune cell

total PBMC: 319 nTPM
naive CD4 T-cell: 243 nTPM
myeloid DC: 226 nTPM
plasmacytoid DC: 215 nTPM
T-reg: 215 nTPM
eosinophil: 198 nTPM

Brain region

cerebral cortex: 460 nTPM
hypothalamus: 429 nTPM
medulla oblongata: 412 nTPM
midbrain: 391 nTPM
pons: 390 nTPM
white matter: 385 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.27
gnomAD pLI: 0.99
gnomAD missense Z: 1.59
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

chromatin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MORF4L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MORF4L1 as an antibody target. Whether an autoantibody or antibody against MORF4L1 could matter depends on whether native MORF4L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MORF4L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MORF4L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...