Seroatlas · Human Serome Atlas

MORF4L2

Mortality factor 4-like protein 2

Also known as: KIAA0026, MO4L2_HUMAN, MRGX

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15014
Gene: MORF4L2
Ensembl: ENSG00000123562
Chromosome: X
Canonical length: 288 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Involved in positive regulation of double-strand break repair via homologous recombination and regulation of cell cycle. Located in nucleolus; nucleoplasm; and plasma membrane. Part of NuA4 histone acetyltransferase complex and nucleosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

288 residues, UniProt reviewed canonical sequence.

>Q15014|MORF4L2
     1  MSSRKQGSQP RGQQSAEEEN FKKPTRSNMQ RSKMRGASSG KKTAGPQQKN LEPALPGRWG
    61  GRSAENPPSG SVRKTRKNKQ KTPGNGDGGS TSEAPQPPRK KRARADPTVE SEEAFKNRME
   121  VKVKIPEELK PWLVEDWDLV TRQKQLFQLP AKKNVDAILE EYANCKKSQG NVDNKEYAVN
   181  EVVAGIKEYF NVMLGTQLLY KFERPQYAEI LLAHPDAPMS QVYGAPHLLR LFVRIGAMLA
   241  YTPLDEKSLA LLLGYLHDFL KYLAKNSASL FTASDYKVAS AEYHRKAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MORF4L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 359 nTPM

Expression across tissuesHPA

Tissue

ovary: 359 nTPM
smooth muscle: 307 nTPM
endometrium: 260 nTPM
blood vessel: 254 nTPM
hypothalamus: 242 nTPM
cervix: 234 nTPM

Single-cell type

extravillous trophoblasts: 1,860 nCPM
decidual stromal cells: 986 nCPM
migrating cytotrophoblasts: 947 nCPM
syncytiotrophoblasts: 798 nCPM
ovarian stromal cells: 768 nCPM
peritubular myoid cells: 695 nCPM

Immune cell

plasmacytoid DC: 70 nTPM
basophil: 55 nTPM
non-classical monocyte: 48 nTPM
MAIT T-cell: 47 nTPM
NK-cell: 46 nTPM
intermediate monocyte: 44 nTPM

Brain region

hypothalamus: 255 nTPM
cerebral cortex: 224 nTPM
pons: 218 nTPM
choroid plexus: 199 nTPM
midbrain: 194 nTPM
basal ganglia: 189 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.54
gnomAD pLI: 0.81
gnomAD missense Z: 1.76
DepMap mean gene effect: -0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MORF4L2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MORF4L2 as an antibody target. Whether an autoantibody or antibody against MORF4L2 could matter depends on whether native MORF4L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MORF4L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MORF4L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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