Seroatlas · Human Serome Atlas

DPF2

Zinc finger protein ubi-d4

Also known as: BAF45d, REQ, REQU_HUMAN, SMARCG2, ubi-d4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92785
Gene
DPF2
Ensembl
ENSG00000133884
Chromosome
11
Canonical length
391 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

391 residues, UniProt reviewed canonical sequence.

>Q92785|DPF2
     1  MAAVVENVVK LLGEQYYKDA MEQCHNYNAR LCAERSVRLP FLDSQTGVAQ SNCYIWMEKR
    61  HRGPGLASGQ LYSYPARRWR KKRRAHPPED PRLSFPSIKP DTDQTLKKEG LISQDGSSLE
   121  ALLRTDPLEK RGAPDPRVDD DSLGEFPVTN SRARKRILEP DDFLDDLDDE DYEEDTPKRR
   181  GKGKSKGKGV GSARKKLDAS ILEDRDKPYA CDICGKRYKN RPGLSYHYAH SHLAEEEGED
   241  KEDSQPPTPV SQRSEEQKSK KGPDGLALPN NYCDFCLGDS KINKKTGQPE ELVSCSDCGR
   301  SGHPSCLQFT PVMMAAVKTY RWQCIECKCC NICGTSENDD QLLFCDDCDR GYHMYCLTPS
   361  MSEPPEGSWS CHLCLDLLKE KASIYQNQNS S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DPF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • endometrium: 37 nTPM
  • ovary: 37 nTPM
  • testis: 37 nTPM
  • skeletal muscle: 37 nTPM
  • cervix: 37 nTPM
  • spinal cord: 36 nTPM

Single-cell type

  • oocytes: 180 nCPM
  • differentiating spermatogonia: 79 nCPM
  • leydig cells: 75 nCPM
  • early primary spermatocytes: 69 nCPM
  • ovarian stromal cells: 64 nCPM
  • peritubular myoid cells: 62 nCPM

Immune cell

  • basophil: 138 nTPM
  • neutrophil: 117 nTPM
  • eosinophil: 100 nTPM
  • NK-cell: 88 nTPM
  • total PBMC: 78 nTPM
  • naive B-cell: 77 nTPM

Brain region

  • white matter: 35 nTPM
  • basal ganglia: 30 nTPM
  • spinal cord: 28 nTPM
  • midbrain: 28 nTPM
  • cerebellum: 27 nTPM
  • medulla oblongata: 27 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DPF2.

Disease | AllUniProt

Conditions DPF2 is implicated in, by any mechanism.

Disease | GeneticClinVar

19 pathogenic / likely-pathogenic of 276 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.16
gnomAD pLI
1
gnomAD missense Z
2.9
DepMap mean gene effect
-0.36
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DPF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DPF2 as an antibody target. Whether an autoantibody or antibody against DPF2 could matter depends on whether native DPF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DPF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DPF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DPF2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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