Seroatlas · Human Serome Atlas

PHF10

PHD finger protein 10

Also known as: BAF45a, FLJ10975, PHF10_HUMAN, SMARCG4, XAP135

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WUB8
Gene
PHF10
Ensembl
ENSG00000130024
Chromosome
6
Canonical length
498 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene contains a predicted ORF that encodes a protein with two zinc finger domains. The function of the encoded protein is not known. Sequence analysis suggests that multiple alternatively spliced transcript variants are derived from this gene but the full-length nature of only two of them is known. These two splice variants encode different isoforms. A pseudogene for this gene is located on Xq28. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

498 residues, UniProt reviewed canonical sequence.

>Q8WUB8|PHF10
     1  MAAAAGPGAA LSPRPCDSDP ATPGAQSPKD DNEDNSNDGT QPSKRRRMGS GDSSRSCETS
    61  SQDLGFSYYP AENLIEYKWP PDETGEYYML QEQVSEYLGV TSFKRKYPDL ERRDLSHKEK
   121  LYLRELNVIT ETQCTLGLTA LRSDEVIDLM IKEYPAKHAE YSVILQEKER QRITDHYKEY
   181  SQMQQQNTQK VEASKVPEYI KKAAKKAAEF NSNLNRERME ERRAYFDLQT HVIQVPQGKY
   241  KVLPTERTKV SSYPVALIPG QFQEYYKRYS PDELRYLPLN TALYEPPLDP ELPALDSDGD
   301  SDDGEDGRGD EKRKNKGTSD SSSGNVSEGE SPPDSQEDSF QGRQKSKDKA ATPRKDGPKR
   361  SVLSKSVPGY KPKVIPNAIC GICLKGKESN KKGKAESLIH CSQCENSGHP SCLDMTMELV
   421  SMIKTYPWQC MECKTCIICG QPHHEEEMMF CDMCDRGYHT FCVGLGAIPS GRWICDCCQR
   481  APPTPRKVGR RGKNSKEG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PHF10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
77 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 77 nTPM
  • skeletal muscle: 72 nTPM
  • adrenal gland: 70 nTPM
  • tongue: 60 nTPM
  • spinal cord: 57 nTPM
  • tonsil: 56 nTPM

Single-cell type

  • adrenal cortex cells: 189 nCPM
  • somatotrophs: 100 nCPM
  • respiratory deuterosomal cells: 79 nCPM
  • endometrial glandular cells: 69 nCPM
  • esophageal apical cells: 66 nCPM
  • salivary ionocytes: 65 nCPM

Immune cell

  • eosinophil: 2.6 nTPM
  • memory B-cell: 2.4 nTPM
  • naive CD8 T-cell: 2.2 nTPM
  • memory CD4 T-cell: 2.1 nTPM
  • naive CD4 T-cell: 2.1 nTPM
  • memory CD8 T-cell: 1.6 nTPM

Brain region

  • spinal cord: 72 nTPM
  • midbrain: 71 nTPM
  • white matter: 69 nTPM
  • thalamus: 68 nTPM
  • pons: 68 nTPM
  • basal ganglia: 68 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0
gnomAD missense Z
1.79
DepMap mean gene effect
0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PHF10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PHF10 as an antibody target. Whether an autoantibody or antibody against PHF10 could matter depends on whether native PHF10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PHF10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PHF10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PHF10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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