Small GTPase superfamily, Rab
IPR050305
Definition
The Rab family of small GTPases is a group of proteins that play a crucial role in regulating intracellular membrane trafficking. They are involved in various stages of vesicular transport, including vesicle formation, movement, tethering, and fusion with target membranes. Members of the Rab family cycle between an inactive GDP-bound form and an active GTP-bound form, recruiting different downstream effectors necessary for vesicular trafficking processes. They are key regulators in processes such as exocytosis, endocytic recycling, and ciliogenesis. Some Rabs are involved in specific pathways like insulin-induced glucose transporter trafficking to the plasma membrane, which is important for glucose homeostasis. Others participate in the establishment and maintenance of cell polarity, neurotransmitter release, and the assembly of tight junctions. The Rab family also has roles in autophagy, axonogenesis, and the regulation of endoplasmic reticulum dynamics.
17 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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