UDP-glycosyltransferase
IPR050271
Definition
The UDP-glycosyltransferase family is involved in phase II biotransformation reactions, where they conjugate lipophilic substrates with glucuronic acid to enhance water solubility and facilitate excretion. They play a crucial role in detoxifying xenobiotics and metabolizing endogenous compounds, including steroid hormones and bile acids. Some family members also contribute to the biosynthesis of complex lipids and glycosides, influencing processes like olfaction and insect development. The family includes enzymes that act on a variety of substrates, from small phenolic compounds to large steroid molecules, and are implicated in the metabolism of drugs, such as angiotensin receptor antagonists and anticancer agents.
22 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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