Seroatlas · Human Serome Atlas

UGT8

2-hydroxyacylsphingosine 1-beta-galactosyltransferase

Also known as: CGT, CGT_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16880
Gene: UGT8
Ensembl: ENSG00000174607
Chromosome: 4
Canonical length: 541 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

The protein encoded by this gene belongs to the UDP-glycosyltransferase family. It catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central and peripheral nervous systems. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

541 residues, UniProt reviewed canonical sequence.

>Q16880|UGT8
     1  MKSYTPYFIL LWSAVGIAKA AKIIIVPPIM FESHMYIFKT LASALHERGH HTVFLLSEGR
    61  DIAPSNHYSL QRYPGIFNST TSDAFLQSKM RNIFSGRLTA IELFDILDHY TKNCDLMVGN
   121  HALIQGLKKE KFDLLLVDPN DMCGFVIAHL LGVKYAVFST GLWYPAEVGA PAPLAYVPEF
   181  NSLLTDRMNL LQRMKNTGVY LISRLGVSFL VLPKYERIMQ KYNLLPEKSM YDLVHGSSLW
   241  MLCTDVALEF PRPTLPNVVY VGGILTKPAS PLPEDLQRWV NGANEHGFVL VSFGAGVKYL
   301  SEDIANKLAG ALGRLPQKVI WRFSGPKPKN LGNNTKLIEW LPQNDLLGHS KIKAFLSHGG
   361  LNSIFETIYH GVPVVGIPLF GDHYDTMTRV QAKGMGILLE WKTVTEKELY EALVKVINNP
   421  SYRQRAQKLS EIHKDQPGHP VNRTIYWIDY IIRHNGAHHL RAAVHQISFC QYFLLDIAFV
   481  LLLGAALLYF LLSWVTKFIY RKIKSLWSRN KHSTVNGHYH NGILNGKYKR NGHIKHEKKV
   541  K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UGT8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 244 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 244 nTPM
midbrain: 70 nTPM
cerebral cortex: 64 nTPM
hippocampal formation: 55 nTPM
basal ganglia: 35 nTPM
hypothalamus: 30 nTPM

Single-cell type

oligodendrocytes: 851 nCPM
renal collecting duct intercalated cells: 300 nCPM
loop of henle epithelial cells: 243 nCPM
oligodendrocyte progenitor cells: 135 nCPM
tuft cells: 92 nCPM
distal convoluted tubule cells: 88 nCPM

Immune cell

naive B-cell: 11 nTPM
memory B-cell: 6.9 nTPM
eosinophil: 0.8 nTPM
MAIT T-cell: 0.6 nTPM
total PBMC: 0.3 nTPM
naive CD4 T-cell: 0.2 nTPM

Brain region

white matter: 546 nTPM
medulla oblongata: 479 nTPM
cerebellum: 356 nTPM
pons: 344 nTPM
basal ganglia: 318 nTPM
spinal cord: 294 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.64
gnomAD pLI: 0.03
gnomAD missense Z: 1.66
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity
N-acylsphingosine galactosyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UGT8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UGT8 as an antibody target. Whether an autoantibody or antibody against UGT8 could matter depends on whether native UGT8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UGT8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UGT8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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