Seroatlas · Human Serome Atlas

UGT2A1

UDP-glucuronosyltransferase 2A1

Also known as: UD2A1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DTE4
Gene: UGT2A1
Ensembl: ENSG00000173610
Chromosome: 4
Canonical length: 527 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene belongs to the UDP-glycosyltransferase family. Members of this protein family play a role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The encoded enzyme is expressed in the olfactory neuroepithelium, which lines the posterior nasal cavity and is exposed to a wide range of odorants and airborne toxic compounds. Hence, this protein has been suggested to be involved in clearing lipophilic odorant molecules from the sensory epithelium. This gene shares exon structure with the UDP glucuronosyltransferase 2A2 family member, which encodes N-terminally distinct isoforms. Polymorphisms in this gene may be associated with the loss of taste and smell that is reported by some individuals during SARS-CoV-2 infection. [provided by RefSeq, Jan 2022]

Canonical amino-acid sequenceUniProt

527 residues, UniProt reviewed canonical sequence.

>P0DTE4|UGT2A1
     1  MLNNLLLFSL QISLIGTTLG GNVLIWPMEG SHWLNVKIII DELIKKEHNV TVLVASGALF
    61  ITPTSNPSLT FEIYKVPFGK ERIEGVIKDF VLTWLENRPS PSTIWRFYQE MAKVIKDFHM
   121  VSQEICDGVL KNQQLMAKLK KSKFEVLVSD PVFPCGDIVA LKLGIPFMYS LRFSPASTVE
   181  KHCGKVPYPP SYVPAVLSEL TDQMSFTDRI RNFISYHLQD YMFETLWKSW DSYYSKALGG
   241  LLLCCPGWSA VADLGSLQPL LPGFKRFSRL SLHCSWDYRL PAGRPTTLCE TMGKAEIWLI
   301  RTYWDFEFPR PYLPNFEFVG GLHCKPAKPL PKVLWRYKGK KPATLGNNTQ LFDWIPQNDL
   361  LGHPKTKAFI THGGTNGIYE AIYHGVPMVG VPMFADQPDN IAHMKAKGAA VEVNLNTMTS
   421  VDLLSALRTV INEPSYKENA MRLSRIHHDQ PVKPLDRAVF WIEFVMRHKG AKHLRVAAHD
   481  LTWFQYHSLD VIGFLLVCVT TAIFLVIQCC LFSCQKFGKI GKKKKRE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UGT2A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 6.4 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 6.4 nTPM
pituitary gland: 3.9 nTPM
kidney: 1.5 nTPM
liver: 1.2 nTPM
skin: 0.6 nTPM
seminal vesicle: 0.1 nTPM

Single-cell type

gonadotrophs: 116 nCPM
respiratory secretory cells: 30 nCPM
respiratory basal cells: 21 nCPM
conjunctival goblet cells: 19 nCPM
respiratory deuterosomal cells: 11 nCPM
respiratory ionocytes: 5.1 nCPM

Immune cell

basophil: 0.2 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 7.6 nTPM
cerebellum: 0.5 nTPM
hippocampal formation: 0.5 nTPM
white matter: 0.5 nTPM
amygdala: 0.3 nTPM
basal ganglia: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
gnomAD missense Z: -1.77
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

glucuronosyltransferase activity

Cellular components

endoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UGT2A1 as an antibody target. Whether an autoantibody or antibody against UGT2A1 could matter depends on whether native UGT2A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UGT2A1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UGT2A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...