UGT1A10

Protein identityUniProt · HPA

UniProt accession

Q9HAW8

Gene

UGT1A10

Ensembl

ENSG00000242515

Chromosome

2

Canonical length

530 aa

Protein class

Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

Secretome location

Intracellular and membrane

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

530 residues, UniProt reviewed canonical sequence.

>Q9HAW8|UGT1A10
     1  MARAGWTSPV PLCVCLLLTC GFAEAGKLLV VPMDGSHWFT MQSVVEKLIL RGHEVVVVMP
    61  EVSWQLERSL NCTVKTYSTS YTLEDQNREF MVFAHAQWKA QAQSIFSLLM SSSSGFLDLF
   121  FSHCRSLFND RKLVEYLKES SFDAVFLDPF DTCGLIVAKY FSLPSVVFTR GIFCHHLEEG
   181  AQCPAPLSYV PNDLLGFSDA MTFKERVWNH IVHLEDHLFC QYLFRNALEI ASEILQTPVT
   241  AYDLYSHTSI WLLRTDFVLD YPKPVMPNMI FIGGINCHQG KPLPMEFEAY INASGEHGIV
   301  VFSLGSMVSE IPEKKAMAIA DALGKIPQTV LWRYTGTRPS NLANNTILVK WLPQNDLLGH
   361  PMTRAFITHA GSHGVYESIC NGVPMVMMPL FGDQMDNAKR METKGAGVTL NVLEMTSEDL
   421  ENALKAVIND KSYKENIMRL SSLHKDRPVE PLDLAVFWVE FVMRHKGAPH LRPAAHDLTW
   481  YQYHSLDVIG FLLAVVLTVA FITFKCCAYG YRKCLGKKGR VKKAHKSKTH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UGT1A10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

75 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.74

gnomAD pLI

0

gnomAD missense Z

-1.4

DepMap mean gene effect

0.05

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• flavone metabolic process
• glucuronate metabolic process
• lipid metabolic process
• liver development
• negative regulation of fatty acid metabolic process
• toxin catabolic process
• xenobiotic catabolic process
• xenobiotic metabolic process

Molecular functions

• enzyme binding
• enzyme inhibitor activity
• glucuronosyltransferase activity
• protein heterodimerization activity
• protein homodimerization activity
• protein kinase C binding

Cellular components

• endoplasmic reticulum
• endoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

• UDP-glucuronosyl/UDP-glucosyltransferase
• UDP-glycosyltransferase family, conserved site
• UDP-glycosyltransferase
• UDP-glucoronosyl and UDP-glucosyl transferase

KeywordsUniProt

• Endoplasmic reticulum
• Glycoprotein
• Glycosyltransferase
• Lipid metabolism
• Membrane
• Signal
• Transferase
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of UGT1A10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• UGT1A1
• UGT1A3
• UGT1A4
• UGT1A6
• UGT1A7
• UGT1A8
• UGT1A9
• UGT1A5