Seroatlas · Human Serome Atlas

UGT2B10

UDP-glucuronosyltransferase 2B10

Also known as: UDB10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P36537
Gene: UGT2B10
Ensembl: ENSG00000109181
Chromosome: 4
Canonical length: 528 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable UDP-glycosyltransferase activity. Predicted to be involved in estrogen metabolic process. Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

528 residues, UniProt reviewed canonical sequence.

>P36537|UGT2B10
     1  MALKWTTVLL IQLSFYFSSG SCGKVLVWAA EYSLWMNMKT ILKELVQRGH EVTVLASSAS
    61  ILFDPNDSST LKLEVYPTSL TKTEFENIIM QLVKRLSEIQ KDTFWLPFSQ EQEILWAIND
   121  IIRNFCKDVV SNKKLMKKLQ ESRFDIVFAD AYLPCGELLA ELFNIPFVYS HSFSPGYSFE
   181  RHSGGFIFPP SYVPVVMSKL SDQMTFMERV KNMLYVLYFD FWFQIFNMKK WDQFYSEVLG
   241  RPTTLSETMR KADIWLMRNS WNFKFPHPFL PNVDFVGGLH CKPAKPLPKE MEEFVQSSGE
   301  NGVVVFSLGS MVSNMTEERA NVIATALAKI PQKVLWRFDG NKPDALGLNT RLYKWIPQND
   361  LLGHPKTRAF ITHGGANGIY EAIYHGIPMV GIPLFFDQPD NIAHMKAKGA AVRVDFNTMS
   421  STDLLNALKT VINDPSYKEN IMKLSRIQHD QPVKPLDRAV FWIEFVMRHK GAKHLRVAAH
   481  NLTWFQYHSL DVIGFLLACV ATVLFIITKC CLFCFWKFAR KGKKGKRD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UGT2B10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 219 nTPM

Expression across tissuesHPA

Tissue

liver: 219 nTPM
gallbladder: 1.4 nTPM
testis: 0.6 nTPM
colon: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

hepatocytes: 14 nCPM
early spermatids: 3.5 nCPM
late primary spermatocytes: 2.9 nCPM
late spermatids: 0.7 nCPM
undifferentiated spermatogonia: 0.2 nCPM
loop of henle epithelial cells: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 0.4 nTPM
medulla oblongata: 0.4 nTPM
white matter: 0.4 nTPM
amygdala: 0.3 nTPM
basal ganglia: 0.3 nTPM
cerebellum: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.64
gnomAD pLI: 0
gnomAD missense Z: -2.86

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

UDP-glycosyltransferase activity

Cellular components

endoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UGT2B10 as an antibody target. Whether an autoantibody or antibody against UGT2B10 could matter depends on whether native UGT2B10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UGT2B10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UGT2B10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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