UGT2B17
UDP-glucuronosyltransferase 2B17
Also known as: UDB17_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O75795
- Gene
- UGT2B17
- Ensembl
- ENSG00000197888
- Chromosome
- 4
- Canonical length
- 530 aa
- Protein class
- Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
OverviewNCBI Gene
This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Copy number variation in this gene is associated with susceptibility to osteoporosis.[provided by RefSeq, Apr 2010]
Canonical amino-acid sequenceUniProt
530 residues, UniProt reviewed canonical sequence.
>O75795|UGT2B17
1 MSLKWMSVFL LMQLSCYFSS GSCGKVLVWP TEYSHWINMK TILEELVQRG HEVIVLTSSA
61 SILVNASKSS AIKLEVYPTS LTKNDLEDFF MKMFDRWTYS ISKNTFWSYF SQLQELCWEY
121 SDYNIKLCED AVLNKKLMRK LQESKFDVLL ADAVNPCGEL LAELLNIPFL YSLRFSVGYT
181 VEKNGGGFLF PPSYVPVVMS ELSDQMIFME RIKNMIYMLY FDFWFQAYDL KKWDQFYSEV
241 LGRPTTLFET MGKAEMWLIR TYWDFEFPRP FLPNVDFVGG LHCKPAKPLP KEMEEFVQSS
301 GENGIVVFSL GSMISNMSEE SANMIASALA QIPQKVLWRF DGKKPNTLGS NTRLYKWLPQ
361 NDLLGHPKTK AFITHGGTNG IYEAIYHGIP MVGIPLFADQ HDNIAHMKAK GAALSVDIRT
421 MSSRDLLNAL KSVINDPIYK ENIMKLSRIH HDQPVKPLDR AVFWIEFVMR HKGAKHLRVA
481 AHNLTWIQYH SLDVIAFLLA CVATMIFMIT KCCLFCFRKL AKTGKKKKRDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against UGT2B17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.25
- Highest tissue expression
- 357 nTPM
Expression across tissuesHPA
Tissue
- small intestine: 357 nTPM
- duodenum: 283 nTPM
- colon: 280 nTPM
- liver: 104 nTPM
- rectum: 97 nTPM
- appendix: 31 nTPM
Single-cell type
- enteric transient amplifying cells: 157 nCPM
- colonocytes: 151 nCPM
- enteric stem cells: 140 nCPM
- endometrial secretory cells: 45 nCPM
- endometrial ciliated cells: 24 nCPM
- goblet cells: 21 nCPM
Immune cell
- naive B-cell: 15 nTPM
- memory B-cell: 4 nTPM
- total PBMC: 0.4 nTPM
- MAIT T-cell: 0.2 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
Brain region
- cerebellum: 2.8 nTPM
- choroid plexus: 2 nTPM
- cerebral cortex: 1.9 nTPM
- pons: 1.8 nTPM
- basal ganglia: 1.7 nTPM
- hypothalamus: 1.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.05
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.69
- DepMap mean gene effect
- 0.09
- DepMap dependency class
- none
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads UGT2B17 as an antibody target. Whether an autoantibody or antibody against UGT2B17 could matter depends on whether native UGT2B17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
UGT2B17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label UGT2B17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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