Seroatlas · Human Serome Atlas

UGT2B4

UDP-glucuronosyltransferase 2B4

Also known as: UD2B4_HUMAN, UGT2B11

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P06133
Gene: UGT2B4
Ensembl: ENSG00000156096
Chromosome: 4
Canonical length: 528 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Enables glucuronosyltransferase activity. Involved in estrogen metabolic process and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

528 residues, UniProt reviewed canonical sequence.

>P06133|UGT2B4
     1  MSMKWTSALL LIQLSCYFSS GSCGKVLVWP TEFSHWMNIK TILDELVQRG HEVTVLASSA
    61  SISFDPNSPS TLKFEVYPVS LTKTEFEDII KQLVKRWAEL PKDTFWSYFS QVQEIMWTFN
   121  DILRKFCKDI VSNKKLMKKL QESRFDVVLA DAVFPFGELL AELLKIPFVY SLRFSPGYAI
   181  EKHSGGLLFP PSYVPVVMSE LSDQMTFIER VKNMIYVLYF EFWFQIFDMK KWDQFYSEVL
   241  GRPTTLSETM AKADIWLIRN YWDFQFPHPL LPNVEFVGGL HCKPAKPLPK EMEEFVQSSG
   301  ENGVVVFSLG SMVSNTSEER ANVIASALAK IPQKVLWRFD GNKPDTLGLN TRLYKWIPQN
   361  DLLGHPKTRA FITHGGANGI YEAIYHGIPM VGVPLFADQP DNIAHMKAKG AAVSLDFHTM
   421  SSTDLLNALK TVINDPLYKE NAMKLSRIHH DQPVKPLDRA VFWIEFVMRH KGAKHLRVAA
   481  HDLTWFQYHS LDVTGFLLAC VATVIFIITK CLFCVWKFVR TGKKGKRD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UGT2B4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 1,191 nTPM

Expression across tissuesHPA

Tissue

liver: 1,191 nTPM
heart muscle: 11 nTPM
kidney: 1.2 nTPM
adipose tissue: 0.8 nTPM
lung: 0.6 nTPM
spleen: 0.3 nTPM

Single-cell type

hepatocytes: 1,055 nCPM
cardiomyocytes: 117 nCPM
hepatic stellate cells: 19 nCPM
cholangiocytes: 8 nCPM
adipocytes: 7.3 nCPM
kupffer cells: 5.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.1 nTPM
medulla oblongata: 0.1 nTPM
pons: 0.1 nTPM
thalamus: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: -1.15
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

glucuronosyltransferase activity

Cellular components

endoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UGT2B4 as an antibody target. Whether an autoantibody or antibody against UGT2B4 could matter depends on whether native UGT2B4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UGT2B4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UGT2B4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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