Seroatlas · Human Serome Atlas

UGT2B11

UDP-glucuronosyltransferase 2B11

Also known as: UDB11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75310
Gene: UGT2B11
Ensembl: ENSG00000213759
Chromosome: 4
Canonical length: 529 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables glucuronosyltransferase activity. Involved in estrogen metabolic process. Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

529 residues, UniProt reviewed canonical sequence.

>O75310|UGT2B11
     1  MTLKWTSVLL LIHLSCYFSS GSCGKVLVWA AEYSHWMNMK TILKELVQRG HEVTVLASSA
    61  SILFDPNDAS TLKFEVYPTS LTKTEFENII MQQVKRWSDI RKDSFWLYFS QEQEILWELY
   121  DIFRNFCKDV VSNKKVMKKL QESRFDIVFA DAVFPCGELL AALLNIRFVY SLRFTPGYTI
   181  ERHSGGLIFP PSYIPIVMSK LSDQMTFMER VKNMIYVLYF DFWFQMSDMK KWDQFYSEVL
   241  GRPTTLFETM GKADIWLMRN SWSFQFPHPF LPNVDFVGGF HCKPAKPLPK EMEEFVQSSG
   301  ENGVVVFSLG SVISNMTAER ANVIATALAK IPQKVLWRFD GNKPDALGLN TRLYKWIPQN
   361  DLLGHPKTRA FITHGGANGI YEAIYHGIPM VGIPLFFDQP DNIAHMKAKG AAVRLDFNTM
   421  SSTDLLNALK TVINDPLYKE NIMKLSRIQH DQPVKPLDRA VFWIEFVMPH KGAKHLRVAA
   481  HDLTWFQYHS LDVIGFLLAC VATVIFIITK FCLFCFWKFA RKGKKGKRD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UGT2B11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 225 nTPM

Expression across tissuesHPA

Tissue

breast: 225 nTPM
gallbladder: 11 nTPM
liver: 9.1 nTPM
kidney: 3.3 nTPM
salivary gland: 2.4 nTPM
epididymis: 0.9 nTPM

Single-cell type

breast hormone-responsive cells: 24 nCPM
salivary acinar cells: 22 nCPM
cholangiocytes: 4 nCPM
loop of henle epithelial cells: 1.7 nCPM
fallopian secretory cells: 1.4 nCPM
platelets: 1.4 nCPM

Immune cell

basophil: 4.7 nTPM
eosinophil: 3.6 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.59
gnomAD pLI: 0
gnomAD missense Z: -4.13
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

glucuronosyltransferase activity

Cellular components

endoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UGT2B11 as an antibody target. Whether an autoantibody or antibody against UGT2B11 could matter depends on whether native UGT2B11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UGT2B11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UGT2B11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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