UGT1A9

Protein identityUniProt · HPA

UniProt accession

O60656

Gene

UGT1A9

Ensembl

ENSG00000241119

Chromosome

2

Canonical length

530 aa

Protein class

Cancer-related genes, Enzymes, Metabolic proteins, Predicted membrane proteins

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

530 residues, UniProt reviewed canonical sequence.

>O60656|UGT1A9
     1  MACTGWTSPL PLCVCLLLTC GFAEAGKLLV VPMDGSHWFT MRSVVEKLIL RGHEVVVVMP
    61  EVSWQLGRSL NCTVKTYSTS YTLEDLDREF KAFAHAQWKA QVRSIYSLLM GSYNDIFDLF
   121  FSNCRSLFKD KKLVEYLKES SFDAVFLDPF DNCGLIVAKY FSLPSVVFAR GILCHYLEEG
   181  AQCPAPLSYV PRILLGFSDA MTFKERVRNH IMHLEEHLLC HRFFKNALEI ASEILQTPVT
   241  EYDLYSHTSI WLLRTDFVLD YPKPVMPNMI FIGGINCHQG KPLPMEFEAY INASGEHGIV
   301  VFSLGSMVSE IPEKKAMAIA DALGKIPQTV LWRYTGTRPS NLANNTILVK WLPQNDLLGH
   361  PMTRAFITHA GSHGVYESIC NGVPMVMMPL FGDQMDNAKR METKGAGVTL NVLEMTSEDL
   421  ENALKAVIND KSYKENIMRL SSLHKDRPVE PLDLAVFWVE FVMRHKGAPH LRPAAHDLTW
   481  YQYHSLDVIG FLLAVVLTVA FITFKCCAYG YRKCLGKKGR VKKAHKSKTH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UGT1A9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

428 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.11

gnomAD pLI

0

gnomAD missense Z

-0.94

DepMap mean gene effect

0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• flavone metabolic process
• flavonoid metabolic process
• liver development
• negative regulation of fatty acid metabolic process
• retinoic acid metabolic process
• xenobiotic metabolic process

Molecular functions

• enzyme binding
• enzyme inhibitor activity
• glucuronosyltransferase activity
• identical protein binding
• protein heterodimerization activity
• protein homodimerization activity
• retinoic acid binding

Cellular components

• endoplasmic reticulum
• endoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

• UDP-glucuronosyl/UDP-glucosyltransferase
• UDP-glycosyltransferase family, conserved site
• UDP-glycosyltransferase
• UDP-glucoronosyl and UDP-glucosyl transferase

KeywordsUniProt

• Endoplasmic reticulum
• Glycoprotein
• Glycosyltransferase
• Lipid metabolism
• Membrane
• Signal
• Transferase
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of UGT1A9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• UGT1A1
• UGT1A10
• UGT1A3
• UGT1A4
• UGT1A6
• UGT1A7
• UGT1A8
• UGT1A5