Seroatlas · Human Serome Atlas

UGT2A2

UDP-glucuronosyltransferase 2A2

Also known as: UD2A2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DTE5
Gene
UGT2A2
Ensembl
ENSG00000271271
Chromosome
4
Canonical length
536 aa
Protein class
Enzymes, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene belongs to the UDP-glycosyltransferase family. Members of this protein family play a role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The encoded enzyme is expressed in the olfactory neuroepithelium, which lines the posterior nasal cavity and is exposed to a wide range of odorants and airborne toxic compounds. Hence, this protein has been suggested to be involved in clearing lipophilic odorant molecules from the sensory epithelium. This gene shares exon structure with the UDP glucuronosyltransferase 2A1 family member, which encodes N-terminally distinct isoforms. Polymorphisms in this gene may be associated with the loss of taste and smell that is reported by some individuals during SARS-CoV-2 infection. [provided by RefSeq, Jan 2022]

Canonical amino-acid sequenceUniProt

536 residues, UniProt reviewed canonical sequence.

>P0DTE5|UGT2A2
     1  MVSIRDFTMP KKFVQMLVFN LTLTEVVLSG NVLIWPTDGS HWLNIKIILE ELIQRNHNVT
    61  VLASSATLFI NSNPDSPVNF EVIPVSYKKS NIDSLIEHMI MLWIDHRPTP LTIWAFYKEL
   121  GKLLDTFFQI NIQLCDGVLK NPKLMARLQK GGFDVLVADP VTICGDLVAL KLGIPFMYTL
   181  RFSPASTVER HCGKIPAPVS YVPAALSELT DQMTFGERIK NTISYSLQDY IFQSYWGEWN
   241  SYYSKILGRP TTLCETMGKA EIWLIRTYWD FEFPRPYLPN FEFVGGLHCK PAKPLPKEME
   301  EFIQSSGKNG VVVFSLGSMV KNLTEEKANL IASALAQIPQ KVLWRYKGKK PATLGNNTQL
   361  FDWIPQNDLL GHPKTKAFIT HGGTNGIYEA IYHGVPMVGV PMFADQPDNI AHMKAKGAAV
   421  EVNLNTMTSV DLLSALRTVI NEPSYKENAM RLSRIHHDQP VKPLDRAVFW IEFVMRHKGA
   481  KHLRVAAHDL TWFQYHSLDV IGFLLVCVTT AIFLVIQCCL FSCQKFGKIG KKKKRE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UGT2A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
9.2 nTPM

Expression across tissuesHPA

Tissue

  • liver: 9.2 nTPM
  • kidney: 5.8 nTPM
  • pituitary gland: 1.4 nTPM
  • cervix: 0.1 nTPM
  • skin: 0.1 nTPM
  • adipose tissue: 0 nTPM

Single-cell type

  • choroid plexus epithelial cells: 2.2 nCPM
  • respiratory deuterosomal cells: 1 nCPM
  • gonadotrophs: 0.2 nCPM
  • oligodendrocytes: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 1.5 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.38
gnomAD pLI
0
gnomAD missense Z
-1.7

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UGT2A2 as an antibody target. Whether an autoantibody or antibody against UGT2A2 could matter depends on whether native UGT2A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UGT2A2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UGT2A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UGT2A2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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