Seroatlas · Human Serome Atlas

UGT3A1

UDP-glucuronosyltransferase 3A1

Also known as: FLJ34658, UD3A1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NUS8
Gene: UGT3A1
Ensembl: ENSG00000145626
Chromosome: 5
Canonical length: 523 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Enables glucuronosyltransferase activity. Part of UDP-N-acetylglucosamine transferase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

523 residues, UniProt reviewed canonical sequence.

>Q6NUS8|UGT3A1
     1  MVGQRVLLLV AFLLSGVLLS EAAKILTIST LGGSHYLLLD RVSQILQEHG HNVTMLHQSG
    61  KFLIPDIKEE EKSYQVIRWF SPEDHQKRIK KHFDSYIETA LDGRKESEAL VKLMEIFGTQ
   121  CSYLLSRKDI MDSLKNENYD LVFVEAFDFC SFLIAEKLVK PFVAILPTTF GSLDFGLPSP
   181  LSYVPVFPSL LTDHMDFWGR VKNFLMFFSF SRSQWDMQST FDNTIKEHFP EGSRPVLSHL
   241  LLKAELWFVN SDFAFDFARP LLPNTVYIGG LMEKPIKPVP QDLDNFIANF GDAGFVLVAF
   301  GSMLNTHQSQ EVLKKMHNAF AHLPQGVIWT CQSSHWPRDV HLATNVKIVD WLPQSDLLAH
   361  PSIRLFVTHG GQNSVMEAIR HGVPMVGLPV NGDQHGNMVR VVAKNYGVSI RLNQVTADTL
   421  TLTMKQVIED KRYKSAVVAA SVILHSQPLS PAQRLVGWID HILQTGGATH LKPYAFQQPW
   481  HEQYLIDVFV FLLGLTLGTM WLCGKLLGVV ARWLRGARKV KKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UGT3A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 54 nTPM

Expression across tissuesHPA

Tissue

liver: 54 nTPM
kidney: 48 nTPM
duodenum: 9 nTPM
small intestine: 6.3 nTPM
testis: 5.4 nTPM
skeletal muscle: 2.9 nTPM

Single-cell type

early spermatids: 123 nCPM
late primary spermatocytes: 112 nCPM
hepatocytes: 87 nCPM
proximal tubule cells: 49 nCPM
renal collecting duct principal cells: 36 nCPM
late spermatids: 26 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 2.3 nTPM
basal ganglia: 1.9 nTPM
pons: 1.9 nTPM
white matter: 1.8 nTPM
hypothalamus: 1.7 nTPM
medulla oblongata: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0
gnomAD missense Z: -0.15
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

UDP-N-acetylglucosamine transferase complex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UGT3A1 as an antibody target. Whether an autoantibody or antibody against UGT3A1 could matter depends on whether native UGT3A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UGT3A1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UGT3A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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