UGT2B15
UDP-glucuronosyltransferase 2B15
Also known as: UDB15_HUMAN, UGT2B8
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P54855
- Gene
- UGT2B15
- Ensembl
- ENSG00000196620
- Chromosome
- 4
- Canonical length
- 530 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted membrane proteins
OverviewNCBI Gene
This gene encodes a glycosyltransferase that is invovled in the metabolism and elimination of toxic compounts, both endogenous and of xenobiotic origin. This gene plays a role in the regulation of estrogens and androgens. This locus is present in a cluster of similar genes and pseudogenes on chromosome 4. [provided by RefSeq, Aug 2016]
Canonical amino-acid sequenceUniProt
530 residues, UniProt reviewed canonical sequence.
>P54855|UGT2B15
1 MSLKWTSVFL LIQLSCYFSS GSCGKVLVWP TEYSHWINMK TILEELVQRG HEVTVLTSSA
61 STLVNASKSS AIKLEVYPTS LTKNYLEDSL LKILDRWIYG VSKNTFWSYF SQLQELCWEY
121 YDYSNKLCKD AVLNKKLMMK LQESKFDVIL ADALNPCGEL LAELFNIPFL YSLRFSVGYT
181 FEKNGGGFLF PPSYVPVVMS ELSDQMIFME RIKNMIHMLY FDFWFQIYDL KKWDQFYSEV
241 LGRPTTLFET MGKAEMWLIR TYWDFEFPRP FLPNVDFVGG LHCKPAKPLP KEMEEFVQSS
301 GENGIVVFSL GSMISNMSEE SANMIASALA QIPQKVLWRF DGKKPNTLGS NTRLYKWLPQ
361 NDLLGHPKTK AFITHGGTNG IYEAIYHGIP MVGIPLFADQ HDNIAHMKAK GAALSVDIRT
421 MSSRDLLNAL KSVINDPVYK ENVMKLSRIH HDQPMKPLDR AVFWIEFVMR HKGAKHLRVA
481 AHNLTWIQYH SLDVIAFLLA CVATVIFIIT KFCLFCFRKL AKKGKKKKRDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against UGT2B15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.25
- Highest tissue expression
- 272 nTPM
Expression across tissuesHPA
Tissue
- liver: 272 nTPM
- gallbladder: 73 nTPM
- colon: 20 nTPM
- stomach: 16 nTPM
- small intestine: 12 nTPM
- pancreas: 12 nTPM
Single-cell type
- cholangiocytes: 58 nCPM
- hepatocytes: 44 nCPM
- gastric chief cells: 30 nCPM
- parietal cells: 18 nCPM
- foveolar cells: 13 nCPM
- mucous neck cells: 9.1 nCPM
Immune cell
- naive B-cell: 0.4 nTPM
- eosinophil: 0.2 nTPM
- memory B-cell: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- spinal cord: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.73
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.87
- DepMap mean gene effect
- -0.12
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads UGT2B15 as an antibody target. Whether an autoantibody or antibody against UGT2B15 could matter depends on whether native UGT2B15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
UGT2B15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label UGT2B15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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