UGT2A3
UDP-glucuronosyltransferase 2A3
Also known as: FLJ21934, UD2A3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6UWM9
- Gene
- UGT2A3
- Ensembl
- ENSG00000135220
- Chromosome
- 4
- Canonical length
- 527 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted membrane proteins
OverviewNCBI Gene
Enables glucuronosyltransferase activity. Involved in xenobiotic metabolic process. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
527 residues, UniProt reviewed canonical sequence.
>Q6UWM9|UGT2A3
1 MRSDKSALVF LLLQLFCVGC GFCGKVLVWP CDMSHWLNVK VILEELIVRG HEVTVLTHSK
61 PSLIDYRKPS ALKFEVVHMP QDRTEENEIF VDLALNVLPG LSTWQSVIKL NDFFVEIRGT
121 LKMMCESFIY NQTLMKKLQE TNYDVMLIDP VIPCGDLMAE LLAVPFVLTL RISVGGNMER
181 SCGKLPAPLS YVPVPMTGLT DRMTFLERVK NSMLSVLFHF WIQDYDYHFW EEFYSKALGR
241 PTTLCETVGK AEIWLIRTYW DFEFPQPYQP NFEFVGGLHC KPAKALPKEM ENFVQSSGED
301 GIVVFSLGSL FQNVTEEKAN IIASALAQIP QKVLWRYKGK KPSTLGANTR LYDWIPQNDL
361 LGHPKTKAFI THGGMNGIYE AIYHGVPMVG VPIFGDQLDN IAHMKAKGAA VEINFKTMTS
421 EDLLRALRTV ITDSSYKENA MRLSRIHHDQ PVKPLDRAVF WIEFVMRHKG AKHLRSAAHD
481 LTWFQHYSID VIGFLLACVA TAIFLFTKCF LFSCQKFNKT RKIEKRELocalizationUniProt · AlphaFold · HPA
Whether an antibody against UGT2A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.25
- Highest tissue expression
- 30 nTPM
Expression across tissuesHPA
Tissue
- small intestine: 30 nTPM
- colon: 21 nTPM
- kidney: 20 nTPM
- pancreas: 15 nTPM
- liver: 13 nTPM
- rectum: 8.7 nTPM
Single-cell type
- proximal tubule cells: 109 nCPM
- pancreatic duct cells: 14 nCPM
- loop of henle epithelial cells: 7 nCPM
- enterocytes: 6.6 nCPM
- podocytes: 4.6 nCPM
- enteric transient amplifying cells: 3.9 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.53
- gnomAD pLI
- 0
- gnomAD missense Z
- -1.75
- DepMap mean gene effect
- -0.11
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads UGT2A3 as an antibody target. Whether an autoantibody or antibody against UGT2A3 could matter depends on whether native UGT2A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
UGT2A3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label UGT2A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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